CONITA, 051411131187 (2018) PENGARUH KONSENTRASI CROSSLINKER CaCl2 TERHADAP PELEPASAN CIPROFLOXACIN HCL DARI MIKROSFER ALGINAT. Skripsi thesis, Universitas Airlangga.

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Abstract

Cystic fibrosis is one of the most common life-shortening inherited diseases. Many researchers develop a targeted drug therapy years ago, but the efforts still continue to find the most effective and efficient drug delivery system to enhance the patient quality of life. Ciprofloxacin-alginate microspheres is a delivery system that capable to protect the ciprofloxacin HCl active drug to the environment exposure and control the release. The objective of this study was to investigate effect of CaCl2 crosslinker concentration on the release of ciprofloxacin HCl from alginate microspheres. The result showed that ciprofloxacin-alginate microspheres had sustained release and completed in 24 hours and the release was following zero order kinetic. CaCl2 Crosslinker concentration ( 2%, 3%, 4%) did not have significant differences on the cumulative release percentage and release rate.

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