PENGARUH KOMBINASI POLIMER HIDROFILIK DAN HIDROFOBIK TERHADAP KARAKTERISTIK FISIK SEDIAAN PATCH MELOKSIKAM

JULIO HASIHOLAN, 051411131180 (2018) PENGARUH KOMBINASI POLIMER HIDROFILIK DAN HIDROFOBIK TERHADAP KARAKTERISTIK FISIK SEDIAAN PATCH MELOKSIKAM. Skripsi thesis, Universitas Airlangga.

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Abstract

In this study, matrix type transdermal patch containing meloxicam were prepared using three combinations of polymers of hydroxyl prophyl methylcellulose (HPMC E15), sodium alginat 20 cps, and ethyl cellulose (EC N22) in the different ratios ( 5:5:1 and 6:4:1 ). All the polymers were dissolved in the suitable solvent. All the prepared formulation used solvent evaporation technique. All the formulations were prepared and subjected to physicochemical studies (organoleptic, weight variation, moisture content, flatness, surface morphology, drug content, and homogeneity). The result of physicochemical evaluation show that formula with 6:4:1 ratio of polymer have a high yield in every test of evaluation. From all of this test, the polymeric combination HPMC E15, sodium alginat and EC N22 in composition 6:4:1 is the best choice for further research.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 55-18 Has p
Uncontrolled Keywords: transdermal patches, meloxicam, HPMC E15, sodium alginat, EC N22, physicochemical studies, moisture content, drug content, homogeneity.
Subjects: R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM
JULIO HASIHOLAN, 051411131180UNSPECIFIED
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorEsti Hendradi, Dra., M.Si., Ph.D., Apt.UNSPECIFIED
Thesis advisorAndang Miatmoko, S.Farm., M.Sc., Ph.D., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 28 Dec 2018 05:43
Last Modified: 28 Dec 2018 05:43
URI: http://repository.unair.ac.id/id/eprint/77333
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