KARAKTERISTIK DAN PELEPASAN GENTAMISIN SULFAT DARI MIKROSFER NATRIUM ALGINAT 2,5% PADA SEDIAAN KRIM M/A

MOCH. HENDRA FIRDAUS, 051411131072 (2018) KARAKTERISTIK DAN PELEPASAN GENTAMISIN SULFAT DARI MIKROSFER NATRIUM ALGINAT 2,5% PADA SEDIAAN KRIM M/A. Skripsi thesis, Universitas Airlangga.

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Abstract

The aim of this research is to characterize and release of gentamicin sulphate from sodium alginat 2,5 % as matrix polymer in cream o/w. Gentamicin sulphate microspheres were made by ionotropic gelation method with aerosolization technique. The verification of gentamicin sulphate microspheres was determined using FT-IR. The evaluation of gentamicin sulphate microsphere was determined by yield value and percent moisture content. The release of gentamicin sulphate is affected by the characteristics of microsphere. The result of microspheres characterization include examination of particle size distribution, SEM, swelling index, drug loading, and entrapment efficiency. Release test of gentamicin sulphate was determined using Franz Diffusion cell with phosphate buffer with pH 7,40 + 0,05 as the media. The kinetics release model suitable for gentamicin sulphate cream was first order that showed release of the active ingredient depends on remaining concentration, and gentamicin sulphate microspheres cream was the higuchi model that showed release of the active ingredient through the diffusion process.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.F. 59-18 Fir k
Uncontrolled Keywords: Gentamicin sulphate, Microsphere, Ionotropic gelation, Sodium Alginate, Characterization, Release test.
Subjects: R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi > Farmastika
Creators:
CreatorsNIM/NIDN
MOCH. HENDRA FIRDAUS, 051411131072UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorTutiek Purwanti, Dra., Apt., M.Si.UNSPECIFIED
ContributorWidji Soeratri, Prof. Dr., DEA., Apt.UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 28 Dec 2018 07:27
Last Modified: 28 Dec 2018 07:27
URI: http://repository.unair.ac.id/id/eprint/77348
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