GAMBARAN MIKROSKOPIS TESTIS DAN KUALITAS SPERMA TIKUS PADA UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL 70% TERFRAKSINASI DAUN Justicia gendarussa Burm. f.

SOFYAN KURNIAWAN, 051311133163 (2018) GAMBARAN MIKROSKOPIS TESTIS DAN KUALITAS SPERMA TIKUS PADA UJI TOKSISITAS SUBKRONIK EKSTRAK ETANOL 70% TERFRAKSINASI DAUN Justicia gendarussa Burm. f. Skripsi thesis, Universitas Airlangga.

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Abstract

The ethanolic extract of Justicia gendarussa Burm. f. have been used by Irian Jaya’s people as man contraception drugs. The preclinical trial showed that 60% ethanolic extract of Justicia gendarussa Burm. f. effective inhibits mice fertilization and have no danger toxcicity. Clinical trial phase 1 evaluated safety of 70 % ethanolic extract of Justicia gendarussa Burm. f, there is no effect on subject healthy. Clinical trial phase 2 evaluated efficay of 70 % ethanolic extract of Justicia gendarussa Burm.f, showed that 70 % ethanolic extract of Justicia gendarussa Burm is effective inhibits fertilization. This subchronic toxcicity study evaluted is there any effect of fractionated 70 % ethanolic extract of Justicia gendarussa Burm. f in histological testes and sperm quality. A total of 40 wistar rats divided in 4 groups. The control group was given CMC-Na 0,5 %. The group I was given 40 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. The group II was given 200 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. The group III was given 1000 mg/Kg BW 70 % ethanolic extract of Justicia gendarussa Burm.f. After 90 days all rats was killed sperm from cauda epididimis was collected and testes was evaluated. In this study showed that fractionated 70 % ethanolic extract of Justicia gendarussa Burm.f can decrease motility, viablity and concentration spermatozoa. Fractionated 70 % ethanolic extract of Justicia gendarussa Burm.f can decrease seminifereous tubule diameter’s, increase seminifereous tubule thickness and decrease total spermatogenic cell, but no effect on Leydig cell.

Item Type: Thesis (Skripsi)
Additional Information: KKB KK-2 FF.FT. 27-18 Kur g
Uncontrolled Keywords: Justica gendarussa, 70% ethanolic extract, subchronic toxcicity, sperm, testis
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi > Farmakognosi Fitokimia
Creators:
CreatorsNIM/NIDN
SOFYAN KURNIAWAN, 051311133163UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorBambang Prajogo E.W., Prof. Dr.,MS., Apt.UNSPECIFIED
ContributorWidjiati, Dr. Msi.,DrhUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 31 Dec 2018 07:25
Last Modified: 31 Dec 2018 07:25
URI: http://repository.unair.ac.id/id/eprint/77405
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