PURWANTO, BAMBANG TRI (2014) COMPARISON OF SUPPRESSIVE ACTIVITY OF THE CENTRAL NERVOUS SYSTEM FROM THE NEW DERIVATIVES N-BENZOYLPHENYLUREA. International Journal of Pharmacy and Pharmaceutical Sciences, 6 (2). pp. 452-455. ISSN 0975-1491

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Abstract

Object: To compare the suppressive activity test of the central nervous system and synthesis from the new compound N-benzoylphenilurea and its derivatives. Methods: The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride derivatives. The Central Nervous System (CNS) supressive activity test was done for the N-benzoylphenylura compound and its derivatives by Barbituric Sleeping Time (BST) method. Result and discussion: The yield of the N-benzoilphenylurea was 86% , had a white crystal , the 4-tersierbuthylbenzoyl-phenyl-urea was a white crystal and yield was 60%, the 2,4-dichlorobenzoylphenylurea yield was 81%, and the p-toluolbenzoylphenilurea was 65%. All of them gave one spot in Thin Layer Chromatography with two different eluent. The all compound melting point was different from the N-phenylurea and showed greater. The structure identification from the all new compounds were analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound were N-benzoylphenylurea and its derivatives. The CNS supressive activity test from N-benzoylphenylurea and its derivatives had a greater activity if compare with the standard compound bromisoval. Conclusion: The N-benzoylphenylurea and its derivatives, which were synthesized, had a higher suppressive activity on the central nervous system. The highest compound on suppressive activity in central nervous system is p-toluolbenzoylphenylurea.

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