Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea

Purwanto, Bambang Tri (2014) Design, synthesis and Central Nervous System depressant activity test of the new compound N’-phenyl-N-benzoylurea. World Journal of Pharmaceutical Research, 3 (3). pp. 4797-4808. ISSN 2277-7105

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Official URL: http://www.wjpr.net/dashboard/abstract_id/897

Abstract

Design and synthesis the new compound N’phenyl-N-benzoylurea has been done. N’phenyl-N-benzoylurea was designed by In Silico by Molegro Virtual Docker Program to predict its activity as the central nervous system depressant . The Schotten Baumann method was used for the reaction between N-phenylurea and benzoyl chloride to produced N’-phenyl-N-benzoylurea. The CNS depressant activity test was done for the N’phenyl-N-benzoylurea compound and compared with bromisoval as the standard reference by Barbituric Sleeping Time (BST) method. The compound N’-phenyl-N-benzoylurea bound as well as the standard reference bromisoval with the protein Pro 85, In Silico method. The compound yield was 86% , had a white crystal and gave one spot in Thin Layer Chromatography with two different eluent. The compound melting point was different from the N-phenylurea and showed greater. The structure identification from the new compound was analysed by UV, IR, 1-HNMR and MS, the result showed that the new compound was N’phenyl-N-benzoylurea. The CNS depressant activity test from N’phenyl-N-benzoylurea had a greater activity if compare with the reference compound bromisoval.

Item Type: Article
Uncontrolled Keywords: Design synthesize by In Silico; N’phenyl-N-benzoylurea; CNS depressant activity test.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Purwanto, Bambang Tribambang-t-p@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 06 Jan 2019 03:45
Last Modified: 09 Jan 2019 02:04
URI: http://repository.unair.ac.id/id/eprint/77454
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