Synthesis, molecular docking and anti tumor activity of N,N-Carbonylbis (N-ethylbenzamide)

Diyah, Nuzul Wahyuning and Purwanto, Bambang Tri and Siswandono, Siswandono (2015) Synthesis, molecular docking and anti tumor activity of N,N-Carbonylbis (N-ethylbenzamide). World Journal of Pharmaceutical Sciences, 3 (7). pp. 1324-1329. ISSN 2321-3310

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Abstract

We have designed and synthesized N,N’-carbonylbis(N-ethylbenzamide) to find new urea derivative with antitumor activity. The compound was synthesized from reaction of N,N’-diethylurea and benzoyl chloride in tetrahydrofuran. The designed molecule was docked into binding site of p38 MAP Kinase (pdb. 3HEG) to predict its binding affinity. The antitumor activity was tested in vitro on human breast cancer cell line (MCF-7 and T47D) by MTT assay and compared with hydroxyurea as a reference compound. The synthesis yield 30% and confirmed as N,N’-carbonylbis(N-ethylbenzamide) by spectroscpopic data. The compound showed higher in vitro antitumor activity than hydroxyurea either against MCF-7 or T47D and displayed better in silico binding property. It concluded that the synthesized compound is recommended to be developed further antitumor agents for human breast cancer.

Item Type: Article
Uncontrolled Keywords: N,N’-carbonylbis(N-ethylbenzamide), synthesis, 3HEG, antitumor activity.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Diyah, Nuzul Wahyuningnuzul-w-d@ff.unair.ac.id
Purwanto, Bambang Tribambang-t-p@ff.unair.ac.id
Siswandono, Siswandonosiswandono@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 06 Jan 2019 03:59
Last Modified: 09 Jan 2019 02:08
URI: http://repository.unair.ac.id/id/eprint/77464
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