Effect of Solid Lipid Nanoparttcle SLN and Nano Structure Lipid Carrier NLC System on Antioxidant Stability of Tomato Extract Lipid Cetyl Alcohol and Isopropyl Myristate

Aqilah, Sayyidati and Hendradi, Esti and Rosita, Noorma (2016) Effect of Solid Lipid Nanoparttcle SLN and Nano Structure Lipid Carrier NLC System on Antioxidant Stability of Tomato Extract Lipid Cetyl Alcohol and Isopropyl Myristate. In: Proceeding 1st International Conference on Medicine and Health Sciences, 31 Agustus - 1 September 2016, Jember Indonesia.

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Abstract

Tomato extract was known contains many antioxidants (Chauhan et o/., 2010), such as hycopene, that are easily degraded by UV-B rays. The mechanism lycopene as an antiaging is to reduce skin regeneration and increase the thickness of the epidermis (Sahasrabuddhe, 2011). As an antioxidant, lycopene easily degraded when exposed to light, heat, and oxygen (Chauhan et al., 20LL). drug delivery system based on nanolipid carrier system, such as: Solid Lipid Nanoparticles (SLN) was apropriate to stabilize lycopene, as lipophilic substance (Wissing and Muller,2003; Helgason et al, 2009; and Okonogi dan Riangjanapatee, 2014). One of the limitations of SLN is the drug molecule thtat has been trapped expulsed easily during stordge. lt is caused of the orderdness of lattice lipid crystal. Replacement part of solid lipid using liquid lipid (called as nanostructure lipid carriers or NLC) can reduce the orderdness of lattice lipid crystall and it will repaired it (Kaur et al, 2015). in this research have been tried to be compared the ability of SLN and NLC to improve the stability of antioxidan tomato extract. Using 20% total amount of lipid, extract tomato-SlN made from cetyl alcohol as solid lipid and extract tomato-NLC made from difference ratio between cetyl alcohol and isopropyl myyristate (lPM) such as:9:1 and 7:3. Tween 80 and kollipor were used as surfactant and co-surfactant, IPM was choose because of its enhancer and emollient effect so easily to apply to the skin (Vadgama et al, 2015)

Item Type: Conference or Workshop Item (Paper)
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Aqilah, SayyidatiUNSPECIFIED
Hendradi, Estiesti-h@ff.unair.ac.id
Rosita, Noormanoorma_rosita@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 04 Jan 2019 08:36
Last Modified: 04 Jan 2019 08:36
URI: http://repository.unair.ac.id/id/eprint/77635
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