Sintesis Senyawa Baru 2-klorobenzoil-fenilurea dan uji aktivitasnya sebagai penekan susunan saraf pusat

Purwanto, Bambang Tri (2012) Sintesis Senyawa Baru 2-klorobenzoil-fenilurea dan uji aktivitasnya sebagai penekan susunan saraf pusat. Majalah Artocarpus Media Pharmaceutica Indonesia, 9 (1). ISSN 1411-8734

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Abstract

Abstract: Synthesis of New Compound 2-chlorobenzoylphenilurea and its CNS depressant activity test. Synthesis the new compound 2-chlorobenzoylphenilurea has been done. The Schotten-Baumann method was used for the reaction between N-phenylurea and 2-chlorobenzoyl chloride. The CNS depressant activity test for the N-benzoylphenylura compound was conducted by Barbituric Sleeping Time (BST) method. The yield was 71%, the compound is white crystals and Thin Layer Chromatography with two different eluents. Its melting point gave one than that of the N-phenylurea. The structure identification from the new compound vas analysed by IR, 1 HNMR and MS, the result showed that the new 2--chlorobenzoylphenylurea. The CNS depressant activity test of 2-chlorobenzoyl­phenylurea had a greater activity compared with the standard compound bromisoval

Item Type: Article
Uncontrolled Keywords: synthesis 2-chlorobenzoylphenilurea, CNS depressant activity test, Bar­ bituric Sleeping Time
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
R Medicine > RS Pharmacy and materia medica > RS200-201 Pharmaceutical dosage forms
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Purwanto, Bambang Tribambang-t-p@ff.unair.ac.id
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 06 Jan 2019 04:22
Last Modified: 09 Jan 2019 02:11
URI: http://repository.unair.ac.id/id/eprint/77670
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