ALFANIA CHRISTANTI, 061411131152 (2018) THE EFFECT OF PANDAN (Pandanus AmaryllifoliusRoxb.)LEAVESETHANOL EXTRACT ON HISTOPATHOLOGICALCHANGES OF ETHANOL-INDUCEDGASTRIC MUCOSAL INJURY IN MICE (Mus musculus). Skripsi thesis, Universitas Airlangga.

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Abstract

This study was aimed to observe the effect of pandan (Pandanus amaryllifolius Roxb.) leaves ethanol extract on histopathological changes of ethanol-induced gastric mucosal injury in mice (Mus musculus). Twenty BALB/C mice were randomly divided into five groups. C- is negative control group which were given 0,5 ml drug solvent orally for 8 days. C+was positive control group, mice were pretreated with 0.5 ml drug solvent orally for 8 days, then on the day 8thmice were given ethanol 50% with dosage of 5ml/kg BW orally. Treatment groups were pretreated with Pandanus amaryllifolius Roxb. leaves ethanol extract with dosages of 200 mg/kg BW (T1), 400 mg/kg BW (T2) and 800 mg/kg BW (T30 for 8 days and continued with 5ml/kg BW ethanol 50% administration on day 8thexactly 1 hour after Pandanus amaryllifolius Roxb.leaves ethanol extract administration. The treatments were conducted for 7 days of acclimatization and 9 days of total treatments. At the end of the research, all mice were euthanized by cervical dislocation and gastric were collected. Gastric tissues were processed into histopathological preparation using Hematoxylin-Eosin staining. The result shows significant difference (p<0,05) between C- and C+ groups prove that ethanol 50% can cause gastric mucosal injury. Insignificant difference (P>0,05) found between C- group and treatment groups which means that Pandanus amaryllifolius Roxb. leaves ethanol extract has effect on improvement of histopathological changes of gastric mucosal injury.Dosages of 200, 400 and 800 mg/kg BW of Pandanus amaryllifolius Roxb. leaves ethanol extract have effect on reducing the epithelial damage on mucosa of mice gastric.

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