THE EFFECT OF NICOTINE PER INHALATION ON THE DIAMETER AND EPITHELIUM THICKNESS OF THE SEMINIFEROUS TUBULES OF MALE RATS (Rattus norvegicus)

YEW SHI EN, 061511133292 (2019) THE EFFECT OF NICOTINE PER INHALATION ON THE DIAMETER AND EPITHELIUM THICKNESS OF THE SEMINIFEROUS TUBULES OF MALE RATS (Rattus norvegicus). Skripsi thesis, Universitas Airlangga.

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Abstract

Nicotine is a pharmacologically active component of the tobacco that adversely affects the male reproductive system and fertility. Nicotine administration in experimental animals was found to affect spermatogenesis, epididymal sperm count, motility and the fertilizing potential of sperms. The goal of this work is to assess the level of testicular damage by observing the changes in the diameter and epithelium thickness of seminiferous tubules in male rats that were given nicotine administration per inhalation. Male adult rats were used and divided into five treatment groups; Control group (NaCl 0.9%), P1 (Nicotine 0.5mg/kg), P2 (Nicotine 1.0mg/kg), P3 (Nicotine 2.0mg/kg) and P4 (Nicotine 4.0mg/kg). All groups were given treatment per inhalation for twenty days. The rats were sacrificed where testes were collected for histopathology preparation. The testes were processed for routine paraffin embedding and staining and the sections were examined for histopathological changes. The results show that nicotine administration had an effect on induced varying degrees of structural damage to the seminiferous tubules, with an average decreased diamater and epithelium thickness of seminiferous tubules. The diameter and epithelium thickness of seminiferous tubules in four experimental groups (P1,P2,P3 and P4) reduced compared to the Control group (C). In conclusion, this study proves that nicotine administration does decreases the spermatogenesis of male reproductive system by reducing the diameter and epithelium thickness of seminiferous tubules in testes. It also proves that the level of testicular damage is directly proportional to the dosage of nicotine administrated to male rats.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK KH 02/19 Yew e
Uncontrolled Keywords: nicotine, tubules seminiferous diameter, epithelium thickness, testes.
Subjects: S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF915-919.5 Veterinary pharmacology
Divisions: 06. Fakultas Kedokteran Hewan
Creators:
CreatorsEmail
YEW SHI EN, 061511133292UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorHardany Primarizky, drh., MVMUNSPECIFIED
ContributorWidjiati, Dr., drh., MSi.UNSPECIFIED
Depositing User: Ny Wahyuni -
Date Deposited: 30 Jan 2019 03:13
Last Modified: 30 Jan 2019 03:13
URI: http://repository.unair.ac.id/id/eprint/79695
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