MEKANISME ANTI TOXOPLASMOSIS EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostanaLinn) PADA MENCIT YANG DIINFEKSI Toxoplasma gondii

MIRANTI CANDRARISNA SUNARSO, 011217017340 (2019) MEKANISME ANTI TOXOPLASMOSIS EKSTRAK ETANOL KULIT MANGGIS (Garcinia mangostanaLinn) PADA MENCIT YANG DIINFEKSI Toxoplasma gondii. Disertasi thesis, Universitas Airlangga.

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Abstract

Background:Toxoplasmosis is a dangerous infectious disease caused by Toxoplasma gondii in the blood or tissue. This disease is zoonotic which is a source of transmission from animals to humans. Therapy of herbal medicine for Toxoplasmosis can be determined by looking at IFN, IL-12 and MMP- 9expression, and seeing the level of organ damage. Purpose: to prove the mechanism of antitoxoplasmosis of mangosteen peel extract against Toxoplasma gondii. Methods: The study was divided into two stages. Stage I: determination of the effective dose 50% of mangosteen peel extract against Toxoplasma.gondii. Stage II: mechanism of antitoxoplasmosis of mangosteen peel extract against Toxoplasma gondii. This study used 50 mice divided into five groups: healthy control group (P0) given 0.5% CMC-Na, P1 group without treatment, P2 group given Cotrimoxazole 60mg/kgB, P3 and P4 groups given mangosteen peel extract 200 and 400 mg/kgBW (orally twice a day). After injection of Toxoplasmagondii 102 intraperitonially and given treatment for 5 days then blood samples taken for measurement of SGPT, SGOT, BUN and creatinine; liver and kidney organ samples to determine organ damage, IFN, IL-12 and MMP-9expression. Results: ED 50% at dose of 60mg/kgBW. Mangosteen peel extract 200mg/kgBW (P3) and 400mg/kgBB (P4) with significance (p<0.05) can reduce the number of parasites, levels of SGPT, SGOT, BUN and creatinine, reduce liver and kidney damage, increases IFN and IL-12 and decreases MMP-9 expression. Conclusion: Mangosteen peel extract 200mg/kgBW (P3) was proven as antitoxoplasmosis in mice can reduce the number of parasites, levels of SGPT, SGOT, BUN and creatinine, reduce liver and kidney damage, increases IFN and IL-12 and decreases MMP-9 expression.

Item Type: Thesis (Disertasi)
Additional Information: KKA KK Dis K 01/19 Sun m
Uncontrolled Keywords: antitoxoplasmosis, ethanol extract of mangosteen peel, Toxoplasma gondii
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > RC Internal medicine
Divisions: 09. Sekolah Pasca Sarjana > Ilmu Kedokteran
Creators:
CreatorsEmail
MIRANTI CANDRARISNA SUNARSO, 011217017340UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorSri Agus Sudjarwo, Prof.Dr. . Ph.D., drhUNSPECIFIED
Depositing User: Unnamed user with email indah.fatma@staf.unair.ac.id
Date Deposited: 22 Feb 2019 04:00
Last Modified: 22 Feb 2019 05:06
URI: http://repository.unair.ac.id/id/eprint/80398
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