SINTESIS SENYAWA TURUNAN DIALKILAMINOMETILPINOCEMBRIN MENGGUNAKAN METODE IRADIASI GELOMBANG MIKRO DAN METODE PEMANASAN KONVENSIONAL

BENYAMIN IANUS NOU, 051514153011 (2019) SINTESIS SENYAWA TURUNAN DIALKILAMINOMETILPINOCEMBRIN MENGGUNAKAN METODE IRADIASI GELOMBANG MIKRO DAN METODE PEMANASAN KONVENSIONAL. Thesis thesis, Universitas Airlangga.

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Abstract

Pinocembrin (5,7-dihydroxyflavanone) is one of the primary flavanones which has been reported to have some pharmacological activities. Some of Mannich base derivatives of pinocembrin have been synthesized by Mannich reaction using of microwave irradiation and conventional heating. Reaction of the mixture of pinocembrin and formaldehyde with diethylamine, dibuthylamine, and piperidine, under microwave irradiation resulting in 8-[(N,Ndiethylamino) methyl]pinocembrin chalcone (21.3 %), 6-8-di[(N,Ndibuthylamino) methyl]pinocembrin chalcone (15.1 %), and 6,8-di(piperidine-1- ilmethyl)pinocembrin Chalcone (15.2 %). Reaction of the mixture pinocembrin and formaldehyde with diethylamine, dibuthylamine, and piperidine under conventional heating resulting in 8-[(N,N-diethylamino)methyl]pinocembrin (31.8 %), 8-[(N,N-dibuthylamino)methyl]pinocembrin (18.6 %), and 8-(piperidine-1- ilmethyl)pinocembrin Chalcone (20.6 %). During the reaction of synthesis of Mannich base derivatives of pinocembrin using microwave irradiation, isomerization of flavanones into chalcones were occured

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TF. 12-19 Nou s
Uncontrolled Keywords: Pinocembrin (5,7-dihydroxyflavanone), Mannich reaction, microwave-assisted reaction, conventional heating
Subjects: R Medicine > RS Pharmacy and materia medica > RS1-441 Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
BENYAMIN IANUS NOU, 051514153011UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorHadi Poerwono, Drs., Apt., M.Sc., Ph.DUNSPECIFIED
ContributorJuni Ekowati, Dr., M.Si., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 29 Apr 2019 07:13
Last Modified: 29 Apr 2019 07:13
URI: http://repository.unair.ac.id/id/eprint/82090
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