PENGARUH EMULSI LEMAK INTRAVENA DIPERKAYA MINYAK IKAN TERHADAP RESPONS INFLAMASI PADA ANAK PASCA PEMBEDAHAN GASTROINTESTINAL

Meta Herdiana Hanindita, 011719049301 (2019) PENGARUH EMULSI LEMAK INTRAVENA DIPERKAYA MINYAK IKAN TERHADAP RESPONS INFLAMASI PADA ANAK PASCA PEMBEDAHAN GASTROINTESTINAL. Thesis thesis, Universitas Airlangga.

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Abstract

Background: Surgery can increase morbidity and mortality due to the production of proinflammatory cytokines such as Interleukin (IL) -6, and tumor necrosis factor (TNF)-α. Intravenous fish oil-enriched lipid emulsion (FOLE) contains ω-3 which can reduce the release of proinflammatory cytokines. Influence of FOLE on modulation of inflammatory response compared to the standard Medium Chain Trygliceride (MCT)/Long Chain Tryglyceride (LCT) emulsion in children postgastrointestinal surgery has never been done. Objective: To explain the influence of FOLE on modulation of inflammatory response in children post-gastrointestinal surgery. Method: A randomized controlled trial was conducted in August 2018 - January 2019 at Dr. Soetomo Hospital in children post-gastrointestinal surgery due to esophageal and intestinal atresia that requires parenteral nutrition at least for 3 days. Samples were divided randomly into MCT/LCT and FOLE groups. Laboratory and cytokines parameters are examined before and 3 days after surgery. Results: Of all, 7/14 were male and 7/14 got FOLE. There were no significant differences in Hb, leukocyte, CRP, albumin, SGOT and SGPT levels in both groups. Triglyceride levels were higher in the MCT/LCT group than FOLE (P = 0.041) on day 3. The difference in IL-6 levels was significant between the two groups before (p = 0.048), 3 days after surgery (p = 0.013) and differences in 3 days (p = 0.007). TNF-α levels were not significantly different compared to MCT/LCT at day-3 post surgery (p = 0.796). Conclusion: FOLE can decrease IL-6 and reduce triglyceride levels compared to standard emulsions in postoperative children.

Item Type: Thesis (Thesis)
Additional Information: KKA KK PPDS.IKA. 08-19 Han p
Uncontrolled Keywords: Parenteral Nutrition, Lipid Emulsion, Intestinal Atresia, Esophageal Atresia
Subjects: R Medicine > RD Surgery
R Medicine > RJ Pediatrics
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Anak
Creators:
CreatorsNIM/NIDN
Meta Herdiana Hanindita, 011719049301UNSPECIFIED
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorRoedi Irawan, Dr., dr., Sp.A(K), MKesUNSPECIFIED
ContributorNur Aisiyah Widjaja, dr., Sp.A(K)UNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 19 Jun 2019 01:36
Last Modified: 19 Jun 2019 01:36
URI: http://repository.unair.ac.id/id/eprint/83341
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