MEKANISME PENINGKATAN DENSITAS PADA AMELOGENESIS GIGI JANIN MENCIT DARI INDUK MENCIT YANG DIBERI SERBUK IKAN LAUT (PENELITIAN EKSPERIMENTAL SECARA INVIVO)

SANDY CHRISTIONO, NIM011317017335 (2019) MEKANISME PENINGKATAN DENSITAS PADA AMELOGENESIS GIGI JANIN MENCIT DARI INDUK MENCIT YANG DIBERI SERBUK IKAN LAUT (PENELITIAN EKSPERIMENTAL SECARA INVIVO). Disertasi thesis, Universitas Airlangga.

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Dis.K.17-19 Chr m.pdf
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Abstract

Objective: The mechanism of density in amelogenesis of primary teeth of children whose mothers consume saltwater fish hasn’t been clearly explained yet. Purpose: Explains the density mechanism in the amelogenesis of mice breed from saltwater fish powder (SFP) consuming mothers. Methods: This was a true experimental research with Completely Randomized Design. 16 Pregnant mice (Mus musculus) were divided into 2 treatment groups using purposive sampling. Treatment group (P) was administered SFP 2.17 mg / 0.5 ml 3 times a day every 6-8 hours, while control group (K) was administered CMC mg / 0.5 ml 3 times a day every 6-8 hours. All mice were sacrificed on day 18 prenatal. All research data were replicated 8 times for treatment group, and 7 times for control group. Saphiro-Wilk tests were used to determine normality distribution, Independent T-tests were done for data distributed normally. In the other hand, data were analysed using Mann-Whitney if they weren’t distributed normally. Results: This study proved that SFP administration enhanced the density mechanism in dental enamel amelogenesis through the Amelogenin pathway (B = -0.751), Kallikrein-4 (B = 0.786) and enamel density (B = 0.507). This was confirmed by the increment in FABP expression (p<0.05), Kallikrein-4 (p<0.05), alkaline phosphatase (p<0.05) and enamel density (p<0.05), while reduction were found in Amelogenin (p<0.05) and collagen type 1 (p<0.05). Conclusions: It can be concluded that SFP enhanced tooth enamel density through Amelogenin and kallikrein-4.

Item Type: Thesis (Disertasi)
Additional Information: KKA KK Dis.K.17/19 Chr m
Uncontrolled Keywords: Enamel Density, Amelogenesis, Saltwater Fish Powder, Prenatal
Subjects: R Medicine > RK Dentistry > RK641-667 Prosthetic dentistry. Prosthodontics
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM
SANDY CHRISTIONO, NIM011317017335NIM011317017335
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorSeno Pradopo, Prof. .,drg.,SU.,PhD.,Sp.KGA(K)UNSPECIFIED
Thesis advisorI Ketut Sudiana, Prof Dr. .,Drs.,MsiUNSPECIFIED
Depositing User: Unnamed user with email nafisa@lib.unair.ac.id
Date Deposited: 26 Jun 2019 03:12
Last Modified: 26 Jun 2019 03:12
URI: http://repository.unair.ac.id/id/eprint/83826
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