HUBUNGAN ANTARA ANALGESIK BEKAM PADA NYERI NEUROPATIK DENGAN RESEPTOR OPIOID-μ, RESEPTOR P2X3, RESEPTOR GABA-A, GLT-1, DAN pNR1 PADA TIKUS RATTUS NORVEGICUS YANG MENGALAMI CIDERA KONSTRIKSI KRONIK

HANIK BADRIYAH HIDAYATI, NIM011417017305 (2019) HUBUNGAN ANTARA ANALGESIK BEKAM PADA NYERI NEUROPATIK DENGAN RESEPTOR OPIOID-μ, RESEPTOR P2X3, RESEPTOR GABA-A, GLT-1, DAN pNR1 PADA TIKUS RATTUS NORVEGICUS YANG MENGALAMI CIDERA KONSTRIKSI KRONIK. Doctoral thesis, Universitas Airlangga.

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Abstract

Background: Neuropathic pain due to chronic constriction injury lead to pain behavioral changes and alteration of some substances in dorsal root ganglion and spinal cord. The result of thermal withdrawal latency and immunohistochemical analysis of substances in dorsal root ganglion and spinal cord shows that wet cupping therapy (WCT) has beneficial effects to reduce neuropathic pain in chronic constriction injury (CCI). Obejctive: To evaluate the analgesic effects of WCT against neuropathic pain due to chronic constriction injury in rat dorsal root ganglion and spinal cord. Methods: Four months male Rattus norvegicus rats were divided into five groups, i.e: K0 (negative-controlled), P1 (negative-controlled plus WCT), P2 (Sham-CCI), P3 (CCI) and P4 (CCI plus WCT). WCT two times every week for three weeks with 5 minutes of first cupping using -200 mmHg, ten punctures and 5 minutes of second cupping using -200 mmHg. Results: WCT could reduce neuropathic pain significantly (p<0,05) by increasing the thermal withdrawal latency, reducing P2X3 receptor expression, but significantly increasing opioid-μ receptor, GABA-A receptor, GLT-1 expressions and pNR1 expression (p<0,05). Conclusion: Chronic constriction injury could lead to neuropathic pain. The mechanism of wet cupping therapy to reduce neuropathic pain is through P2X3 receptor, opioid-μ receptor, GABA-A receptor, GLT-1 and pNR1.

Item Type: Thesis (Doctoral)
Additional Information: KKB KK-2 Dis. K. 15 19 Hid h
Uncontrolled Keywords: Cupping therapy, neuropathic pain, CCI, P2X3 receptor, opioid-μ receptor, GABA-A receptor, GLT-1, pNR1
Subjects: R Medicine > RA Public aspects of medicine > RA1-1270 Public aspects of medicine > RA1-418.5 Medicine and the state
Divisions: 01. Fakultas Kedokteran
Creators:
CreatorsNIM
HANIK BADRIYAH HIDAYATI, NIM011417017305NIM011417017305
Contributors:
ContributionNameNIDN / NIDK
Thesis advisorMoh. Hasan, Prof. Dr. Hj., SE.,M.Si., Ak., CA.UNSPECIFIED
Thesis advisorAhmad Faishal Haq, Prof. Dr. KH., M.Ag,UNSPECIFIED
Depositing User: Unnamed user with email dewi@lib.unair.ac.id
Date Deposited: 27 Jun 2019 03:13
Last Modified: 27 Jun 2019 03:13
URI: http://repository.unair.ac.id/id/eprint/84007
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