PENGARUH PAPARAN UAP ROKOK ELEKTRIK TERHADAP GAMBARAN HISTOPATOLOGI ORGAN PULMO TIKUS PUTIH GALUR SPRAGUE DAWLEY

CAROLINA ARDY MEGA PERTIWI, 061511535023 (2019) PENGARUH PAPARAN UAP ROKOK ELEKTRIK TERHADAP GAMBARAN HISTOPATOLOGI ORGAN PULMO TIKUS PUTIH GALUR SPRAGUE DAWLEY. Skripsi thesis, Universitas Airlangga.

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Abstract

Electric cigarettes (e-cigarettes) contain nicotine which cause of lung obstruction. The nicotine exposure in e-cigarette can increase the accumulation off inflammatory cells in pulmo. Nicotine which play role as a free radicals, especially within respiratory system. This study was aimed to identify the histopathology appearance of rat’s pulmo against exposure to e-cigarette. A total of 20 rats which divided in 5 groups, control group (K) were not exposed by e-cigarette and treatment group were exposed by e-cigarette in different doses, P1 (0,3mg/ml), P2 (3mg/ml), P3 (12 mg/ml), P4 (36 mg/ml) respectively. After 14 days of treatment, rats were euthanasia and necropsy method was performed to identify macroscopy change, also the pulmo organs were dissected and preserved for histopathological study using Hematoxilin-Eosin staining. The results, show that damage of pulmo was defected within histopathology examination using 400x magnification. Moreover, the data was analyzed using Kruskal-Wallis test and continued by Mann Whitney Test which show a significant different (P < 0,05). Average result from pulmo organs of Rats Sprague dawley is Control (K) = 3,00; Treatment 1 (P1) (0.3 mg/ml) = 6,00; P2 (3mg/ml) = 12,00 ;P3(12mg/ml) = 13,00 and P4(36mg/ml) = 18,50 and nicotine dose of minimum is 3 mg/ml . In conclude, the exposure of ecigarette have significant damage effect of pulmo organs in rats.

Item Type: Thesis (Skripsi)
Additional Information: KKC KK PSDKU. KH 17/19 Per P
Uncontrolled Keywords: Electric Cigarettes, Histophatology, Pulmo, Sprague dawley.
Subjects: Q Science > QL Zoology > QL750-795 Animal behavior
T Technology > TS Manufactures > TS1950-1982 Animal products
Divisions: 16. PSDKU Banyuwangi > Kedokteran Hewan
Creators:
CreatorsEmail
CAROLINA ARDY MEGA PERTIWI, 061511535023UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorIwan Sahrial Hamid, Dr., drh.,M.SiUNSPECIFIED
ContributorAditya Yudhana, drh.,M.Si.UNSPECIFIED
Depositing User: shiefti dyah alyusi
Date Deposited: 27 Jun 2019 05:26
Last Modified: 27 Jun 2019 05:26
URI: http://repository.unair.ac.id/id/eprint/84094
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