Ira Widjiastuti and Tamara Yuanita and James Hutagalung and Mandojo Rukmo and Indri Safitri Mukono (2014) East Java Propolis Inhibits cytokine Pro-inflammatory in Odontoblast like cells Human Pulp. Journal of Agricultural Science and Technology, 4 (1). pp. 1-10. ISSN 1939-1250

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Abstract

Inflammation in pulp tissue is caused by caries bacteria. Most bacteria found are Lactobacillus acidophilus . Propolis is a sticky resin material that is derived from the bees and the surrounding plants, which are reported to have several biological effects including anti-bacterial and anti-inflammatory. This study will prove the effectiveness of propolis against proinflammatory cytokines on odontoblast like cells in human dental pulp. This study was performed on cultured odontoblast like cells in pulp. Cell culture was derived from the pulp tissue of human M3 teeth that had been extracted. Odontoblast pulp culture was divided in 3 groups, group 1 was cultured cells with propolis; group 2, cultured cells induced with Lactobacillus acidophilus ; group 3, cultured cells induced with inactive Lactobacillus acidophilus and exposed to 3μg/ml propolis. A measurement of TNF-α danTGF-β1 expression was done using the immunocytochemical technique to determine the effectiveness of propolis extracts from East Java Indonesia against proinfalmmatory cytokines. Data were analyzed using Anova test (p= 0,05) . Propolis extract can inhibit the expression of TNFα and increase the expression of TGF-β1on odontoblast like cell in human dental pulp. Anti-inflammatory effects of east Java propolis extract are associated with cytokine modulation

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