Junaidi Khotib, NIDN. 0022107001 and Mahardian Rahmadi, NIDN. 0014038102 and Chrismawan Ardianto, NIDN. 0029028403 and Khoirotin Nisak, NIDN. 0029118501 and Rianur Oktavia and Ayu Ratnasari and Yunita Dinintia and Dewi Wara Shinta, NIDN. 0018108502 and Toetik Aryani and Suharjono (2018) Selective Serotonin Reuptake Inhibitor Fluvoxamine Ameliorates Stress-and NSAID-Induced Peptic Ucler Possibly by involving Hsp70. Journal Basic and Clinical Physiology and Pharmacology, 30 (2). pp. 1-9. ISSN 0792-6855

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	Text (SIMILARITY) Selective serotonin reuptake inhibitor fluvoxamine ameliorates stress- and NSAID-induced peptic ulcer possibly by involving Hsp70.pdf Download (4MB)
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Abstract

Background: Selective serotonin reuptake inhibitors (SSRIs) have recently become potential candidates for a new therapeutic approach to ulcer and gastric bleeding. Heat shock protein 70 (Hsp70) plays an important role in cellular resistance to nonsteroidal anti-inflammatory drugs (NSAIDs). However, there is lack of evidence that fluvoxamine recruits Hsp70 to affect stress-induced gastric ulcer. Therefore, we investigated the effect of fluvoxamine on NSAID- and stress-induced gastric ulcer and the possible involvement of Hsp70. Methods: ICR mice were used in the study. Stress induction was made by the water-immersion-plus-restraint method. NSAID-induced gastric ulcer was produced by oral administration of indomethacin. Fluvoxamine was given orally 30 min before stress induction and indomethacin treatment. Results: Stress and indomethacin treatment significantly increased the ulcer index and intraluminal bleeding score. Stress and indomethacin treatment also significantly increased the expression of Hsp70. Fluvoxamine significantly decreased the ulcer index and intraluminal bleeding in both ulcer models. Moreover, fluvoxamine further increased the expression of Hsp70 in the gastric tissue of stress- and indomethacin-treated mice. Conclusions: Our results indicate that fluvoxamine may have a protective effect against stress- as well as NSAID induced gastric ulcer. In addition, the present study

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