Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats

Meircurius Dwi Condro Surboyo and Diah Savitri Ernawati and Ira Arundina and Retno Pudji Rahayu (2019) Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats. Journal of Krishna Institute of Medical Science University (JKIMSU),, 8 (2). ISSN 2231-4261

[img] Text (VALIDASI)
Validasi (Oral Ulcer).pdf

Download (669kB)
[img] Text (VALIDASI)
Oral Ulcer Healing after Treatment with Distilled Liquid Smoke of Coconut Shell on Diabetic Rats.pdf

Download (4MB)
[img] Text (ARTICLE)
Sularsih_2018_IOP_Conf._Ser.-_Earth_Environ._Sci._217_012030.pdf

Download (823kB)

Abstract

Background: Distilled liquid smoke from coconut shell (Cocos nucifera L.) by pyrolysis process with final temperature 4000C and then distilled in 120-1500C. The characteristics of distilled liquid smoke are yellow liquid, with acidity 2.39 and density 1.0643 g/cm3. The major identified compounds arephenol (36.6%), 2- methoxyphenol (guaiacol) (25.2%), furfural (17.8%), 2-methoxy-5-methylphenol (5.2%) and 4-ethyl-2- methoxyphenol (EMP) (3.5%) with 28 other minor constituents by GCMS. Aim and Objectives: Distilled liquid smoke was examined to investigate its potential therapeutic to oral ulcer healing and diabetic condition on the rat. Furthermore, the clinical oral ulcer healing was evaluated based on ulcer size and diabetic was evaluated based on Fasting Blood Glucose (FBG) and body weight changes. Material and Methods: Diabetes was induced by alloxan. Seventy-two hours after injection, the diabetic condition was confirmed with FBG of >200mg/dl, then the labial fornix anterior was injured to induce oral ulcer using round steel blade. Results: The clinical oral ulcer healing was improved after treatment with distillated liquid smoke compared to benzydamine hydrochloride and aquadest sterile for three days (p=0.005) and seven days (p=0.000). Treatment for seven days with distilled liquid smoke showed significant improvement of the body mass changes compared to benzydamine hydrochloride (p=0.008) and aquadest sterile (p=0.002). There was no improvement of FBG after treatment with distilled liquid smoke (p=0.152). Conclusion: Treatment with distilled liquid smoke coconut shell can improved oral ulcer healing and body weight changes, but not FBG changes.

Item Type: Article
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Patologi & Maxifacial
Creators:
CreatorsNIM/NIDN
Meircurius Dwi Condro SurboyoUNSPECIFIED
Diah Savitri ErnawatiUNSPECIFIED
Ira ArundinaUNSPECIFIED
Retno Pudji RahayuUNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 16 Jul 2019 03:16
Last Modified: 16 Jul 2019 03:16
URI: http://repository.unair.ac.id/id/eprint/84749
Sosial Share:

Actions (login required)

View Item View Item