PROFIL RESISTENSI ANTIRETROVIRAL PADA PASIEN HIV/AIDS DI RSUD Dr. SOETOMO SURABAYA

Erytasha Mahdy Pratama, NIM011511133212 (2018) PROFIL RESISTENSI ANTIRETROVIRAL PADA PASIEN HIV/AIDS DI RSUD Dr. SOETOMO SURABAYA. Skripsi thesis, Universitas Airlangga.

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Abstract

Background: Dr. Soetomo Surabaya general hospital is a referral hospitals in the eastern part of Indonesia. Many HIV/AIDS patients were treated in hospital, so it needs to investigated the profile of ARV resistance. Objectives: The objective of this study was to identify the profile of ARV resistance in treated patients in Dr. Soetomo general hospital. Method: This study was using descriptive – retrospective design. The data of the profile ARV resistance was obtained for treated patients by using medical record. Result: Lamivudine and Nevirapine most often used, the most combination given was Lamivudine + Zidovudine + Nevirapine, the most resistant in Nevirapine and Efavirenz, based on the polymerase region mutase pattern of the NNRTI drug group was in Nevirapine (Y181C 50%) and Efavirenz (V106M 20%) while the NRTI group was in Lamivudine (M184V 12%) and Tenofovir (K65R 6%). Conclusion: Most patients have resistance to Nevirapine and Efavirenz, NNRTI groups on Nevirapine drugs obtained a Y181C, V108I, V106I, G190GA mutation of 47%, whereas in Efavirenz Y181C, V108I, V106I mutations were 41.2%. And from the NRTI group on the Lamivudine drug M184V was obtained, K65R was 29.4%, the Emitricitabine drug was M184V, K65R was 29.4%, Tenofovir was K65R was 11.8%, and Zidovudine was K219QE of 5.9%.

Item Type: Thesis (Skripsi)
Additional Information: KKA KK FK.PD. 45-19 Pra p
Uncontrolled Keywords: HIV, antiretroviral resistance.
Subjects: R Medicine > RC Internal medicine > RC31-1245 Internal medicine
Divisions: 01. Fakultas Kedokteran > Pendidikan Dokter
Creators:
CreatorsNIM/NIDN
Erytasha Mahdy Pratama, NIM011511133212NIM011511133212
Contributors:
ContributionNameNIDN/NIDK/NUP
ContributorJuniastuti, Dr., dr., M.KesUNSPECIFIED
ContributorMuhammad Vitanata Arifijanto, dr., Sp.PD. KPTI. FINASIMUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 09 Jul 2019 10:31
Last Modified: 09 Jul 2019 10:31
URI: http://repository.unair.ac.id/id/eprint/84774
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