Bambang Sektiari Lukiswanto, NIDN. 0008116202 and Wiwik Misaco Yuniarti (2012) Anti Necro-inflammatory Effect of Standardized Punica granatum Extract (40% ellagic acid) on Liver Fibrosis Induced by Bile Duct Ligation in Rats. In: Proceeding International Seminar: Strategy to manage Bio-Eco-Health system for Stabilizing Aminal Health and Productivity to Support Public Health. Airlangga University Publishing, Surabaya, pp. 142-146. ISBN 978-602-8967-69-3

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Abstract

The aim of this study was to evaluate the anti necro-inflammatory effect on liver fibrosis treated by standardized punica granatum extract. A total of thirty two albino rats (Rattus Norwegicus), male, Wistar strain were divided into 4 groups namely sham operated group (group I) and three main bile duct ligation groups (BDL) (group II = BDL, non-treated; group III = BDL, treated by 60 mg/kg body weight/day ellagic acid and group IV = BDL, treated by 150 mg/kg body weight/day standardized punica granatum extract respectively). The results showed a significative decrease of the necro-inflammatory score and fibrosis score for group III and group IV compared to group II but higher than group I (p < 0.05). The necroinflammatory value were higher in the group III compared to others group (p < 0.05). It can be concluded that the administration of 150 mg/kg body weight/day standardized punica granatum extract possessed hepatoprotective activity and avoided progression of fibrosis by its anti necro-inflammatory activity. Keywords: anti necroinflammatory, liver fibrosis, punica granatum extract, bile duct ligation (BDL), hepatoprotective

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