ERYTHROPOIETIN RESTORES MOTOR FUNCTIONS THROUGH ANGIOGENESIS IN THE THALAMUS AREA OF ISCHEMIC STROKE IN RATS

Rifda Naufa Lina and Mahardian Rahmadi, NIDN. 0014038102 and Junaidi Khotib, NIDN. 0022107001 (2018) ERYTHROPOIETIN RESTORES MOTOR FUNCTIONS THROUGH ANGIOGENESIS IN THE THALAMUS AREA OF ISCHEMIC STROKE IN RATS. Folia Medica Indonesia, 54 (3). pp. 189-194. ISSN 2355-8393

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Official URL: https://e-journal.unair.ac.id/FMI/article/view/100...

Abstract

The present study aimed to determine the potency of erythropoietin as angiogenesis inducer in ischemic stroke rats model. Animal model was treated by right unilateral common carotid artery occlusion (rUCCAO) for 90 minutes. The stroke model produced decreased motor function. Eight to 12 week-old Wistar rats were used. rHuEPO was administered for 7 days, starting at 24 hours after stroke induction. Motor functions were measured before and 1, 3 and 7 days after rUCCAO. Whereas, histological damage and VEGF expression were evaluated at day 14. The results showed that rHuEPO significantly increased motor function on day 7, reduced the number of damaged body cell and increased VEGF expression in the thalamus area on day 14. As a conclusion, rHuEPO may restore the motoric function and prevent brain neuronal death by inducing angiogenesis through the increase in the expression of VEGF in rUCCAO-induced ischemic stroke model.

Item Type: Article
Uncontrolled Keywords: rHuEPO; ischemic stroke; motor function; angiogenesis; VEGF
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Rifda Naufa LinaUNSPECIFIED
Mahardian Rahmadi, NIDN. 0014038102UNSPECIFIED
Junaidi Khotib, NIDN. 0022107001UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 15 Aug 2019 08:16
Last Modified: 15 Aug 2019 08:16
URI: http://repository.unair.ac.id/id/eprint/85363
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