Mekanisme Molekuler Antidiabetika Vanadil Sulfat

Junaidi Khotib, NIDN. 0022107001 and Debra Dorotea and Elisabet Kasih and Nur Palestin and Pharmasinta Putri H. and Imam Susilo (2011) Mekanisme Molekuler Antidiabetika Vanadil Sulfat. Majalah Farmasi Airlangga, 9 (1). pp. 16-21. ISSN 0852-1050

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Abstract

Previous study showed that vanadyl sulphate can effectively lowered blood glucose level in streptozotosin-induce diabetic mice. This study is aimed to reveal the molecular mechanism of vanadyl sulphate in lowering blood glucose level. Diabetic mice were given vanadyl sulphate suspension in CMC-Na once a day for 7 days with the following dosage, 3, 30, 100 mg/kg body weight. On day 28, mice were sacrifice and the muscle, liver, adipose tissue and pancreas were taken. Histochemistry staining with haematoxyllin-eosin and fuchsin aldehyde \>>as conducted to observe changes in sellular structure.Changes in molecular level were observed by immunohystochemistry-approach with insulin, glucose transporter-4 telomerase and apoptosis antibody receptors. Results showed that vanadyl sulphate can imporove the morphology of muscle, liver, adipose and /3-pancreas cells that were damaged in streptozotocin induced diabetes. Muscle cells showed significant increase in diameter and glicogen sorage also increased. Fatty cells in the liver also decrease and damage of fatty cells also decrease. These improvement were in correlation with the increase in the activity of insulin receptor and glucose transporter-4 caused by vanadyl sulphate medication

Item Type: Article
Uncontrolled Keywords: Diabetes mellilus, vanadyl sulfphate, protein phosphorilation, glut-4, telomerase
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Junaidi Khotib, NIDN. 0022107001UNSPECIFIED
Debra DoroteaUNSPECIFIED
Elisabet KasihUNSPECIFIED
Nur PalestinUNSPECIFIED
Pharmasinta Putri H.UNSPECIFIED
Imam SusiloUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 14 Aug 2019 08:35
Last Modified: 14 Aug 2019 08:35
URI: http://repository.unair.ac.id/id/eprint/85392
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