Pivotel role reelin signaling pathway in the development of tolerance to morphine-induced antinociception

Bambang Subakti Zulkarnain and Junaidi Khotib, NIDN. 0022107001 (2008) Pivotel role reelin signaling pathway in the development of tolerance to morphine-induced antinociception. Indonesian Journal of Pharmacy, 19 (3). pp. 157-164. ISSN 2338-9486

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Abstract

The huge endogenous macromolecule protein responsible for controlling migration and dendritic growth of developing neurons, reelin, has recently been proposed that its signaling pathway modulates synaptic plasticity in the adult rodent brain. This study was carried out to investigate the pivotal role of the reelin signaling pathway in the development of tolerance to morphine-induced antinociception. There was evidence that repeated intracerebroventricular administration of reeling monoclonal antibody, the competitive inhibitor to reelin - apolipoprotein receptor E2 recombinant, and disabledl (Dabl) protein inhibitor - MG132, resulted in the inhibition to the development of antinociception tolerance to morphine administration. Furthermore, chronic in vivo administration with morphine caused significance increase of the immunoreactivity (IR) for phosphorylatedDabl in the thalamus. These data suggested that persistent activation of reelin signaling pathway due to chronic administration of morphine may be responsible for the development of tolerance to morphine-induced antinociception.

Item Type: Article
Uncontrolled Keywords: Morphine tolerance, Neuronal plasticity, Opioid receptor, Reelin signaling pathway
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Bambang Subakti ZulkarnainUNSPECIFIED
Junaidi Khotib, NIDN. 0022107001UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 14 Aug 2019 08:46
Last Modified: 14 Aug 2019 08:46
URI: http://repository.unair.ac.id/id/eprint/85412
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