Bernadetta Caroline Panjaitan and Ashon Saadi and Hendy Hendarto, 090315218 D and Widjiati (2012) Comparison of ovarial malondialdehyde (mda) level between endometriosis rat given with and without curcumine supplementation. Majalah Obstetri & Ginekologi, 20 (1). pp. 30-34. ISSN 0854-0381

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Abstract

Chronic inflamation at endometriosis causing oxidative stree at granulosa cell which cause unbalance between free radical and anti oxidant. This cause the chains effect continuously and cause the destruction of cell membrane and the last effect is unstable and the fragmentation producing MDA. The role of curcumin as antioxidant can decrease overall MDA titer has not been studied. The objective of this study was to investigate the effect of curcumin to ovarial MDA in endometriosis rat. This was eksperimental laboratory trial with population female 40 rat (Rattus novergicus strain Winstar) which met the inclusion criteria the rats were randomnized and with 20 sample in each group. To become endometriotic the rats were, we injected with cyclosporin A and Ethynil Estradiol intra musculary also injection in endometrial tissue of human benign ovarial tumor in human into intrapertitoneal rat. Treatment group was given curcumine suplementation 24 mg (240 g/kg) every day in 14 days, another group given placebo. All rats were operated to get the ovarial tissue and check the titer MDA was examined with spectrofotometry. There were difference in ovarial MDA titer at in endometriosis rat which given with dan without curcumine suplementation.(p< 0,0001). In conclusion, MDA titer at endometriosis rats with curcumin supplementation is lower than placebo. (MOG 2012;20:30-34)

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