Topical Epigallocatechin-3-gallate Hydrogels Regulated Inflammation and Pain

Kun Ismiyatin, NIDN. 0002046001 and Soegeng Wahluyo, NIDN. 0010115405 and Bambang Purwanto, NIDN. 0028088001 and Adioro Soetojo, NIDN0010085102 and Retno Pudji Rahayu and Indri Safitri Mukono, NIDN. 0014065303 (2009) Topical Epigallocatechin-3-gallate Hydrogels Regulated Inflammation and Pain. Journal of International Dental and Medical Research, 12 (1). pp. 56-60. ISSN 1309100X

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Official URL: http://www.jidmr.com/journal/

Abstract

The aim of this study is to determine in vivo response of topical Epigallocatechin-3-gallate (EGCG) hydrogels to pain and inflammation through Toll-like receptor 4 (TLR4), Superoxide dismutase (SOD1), Prostaglandin E2 (PG-E2) and Transient receptor potential vanilloid 1 (TRPV1) in pulpal inflammation. Rats (n=35) were divided into a normal group (N), a positive control group induced with LPS for 6 hours (C1), a group induced with LPS for 24 hours (C2), a treatment group induced with LPS and topical EGCG 120 μg/ml (T1) for 6 hours and a group induced with LPS and topical EGCG 120 μg/ml for 24 hours (T2). Tissues were collected and observed by means of immunohistochemistry (IHC) to detect the expression of TLR4, SOD1, PG-E2 and TRPV1. Data were analyzed using a One-Way ANOVA test for TLR4, PG-E2 and TRPV1, while SOD1 was analyzed using a Brown-Forsythe test and Games Howell test. Application of topical 120 μg/ml EGCG hydrogels in tooth cavities at 6 hours and 24 hours pulpal inflammation significantly increased the expression of SOD1, while significantly decreasing the expressions of TLR4, PG-E2 and TRPV1 (P< 0.001). EGCG can be used as a pain inhibitor, anti-inflammatory agent and antioxidant agent against pulpal inflammation in rat models.

Item Type: Article
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Concervative
Creators:
CreatorsNIM/NIDN
Kun Ismiyatin, NIDN. 0002046001UNSPECIFIED
Soegeng Wahluyo, NIDN. 0010115405UNSPECIFIED
Bambang Purwanto, NIDN. 0028088001UNSPECIFIED
Adioro Soetojo, NIDN0010085102UNSPECIFIED
Retno Pudji RahayuUNSPECIFIED
Indri Safitri Mukono, NIDN. 0014065303UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 23 Aug 2019 03:36
Last Modified: 23 Aug 2019 03:36
URI: http://repository.unair.ac.id/id/eprint/85739
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