Therapeutic Efficacy of Topical Epigallocatechin-Gallate as a New Therapeutic Strategy for Inhibition of Pain Conduction on Rat Models with Acute Pulpal Inflammation

Kun Ismiyatin, NIDN. 0002046001 and Adioro Soetojo, NIDN0010085102 and Soegeng Wahluyo, NIDN. 0010115405 and Indri Safitri Mukono, NIDN. 0014065303 (2017) Therapeutic Efficacy of Topical Epigallocatechin-Gallate as a New Therapeutic Strategy for Inhibition of Pain Conduction on Rat Models with Acute Pulpal Inflammation. In: Proceedings of International Medical Device and Technology Conference (iMEDiTEC 2017). Universiti Teknologi Malaysia, Johor Bahru. ISBN 978-967-0194-93-6

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Official URL: http://www.utm.my/imeditec2017/files/2017/10/P30_T...

Abstract

The pulpal inflammation can lead to elicit pain in trigeminal nociceptor, produces prostaglandin (PG-E2), activating transient receptor potential vanilloid (TRPV1), causing substance P (SP) release. Here, we investigated the potential of epigallocatechin 3-gallate (EGCG) for topical medication to inhibit pain conduction in pulpal inflammation. This research on 28 male Wistar rats (Rattus norvegicus) as rat models with pulpal inflammation. Topical 0.01% or 0.1% EGCG was applied to the tooth cavity of pulpal inflammation. The treated pulp tissues were then observed using immunohistochemistry (IHC), and calculation of the amount of PG-E2, TRPV1 and SP. Results show the treatment with topical 0.1% EGCG in 24 hours pulpal inflammation showed a significant inhibit the expression of PG-E2, TRPV1, and SP compared with 0.01% EGCG, and untreated controls (P< 0.001). In conclusion, the results suggest a potential to inhibiting pain conduction of 0.1% topical EGCG in pulpal inflammation.

Item Type: Book Section
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Concervative
Creators:
CreatorsNIM/NIDN
Kun Ismiyatin, NIDN. 0002046001UNSPECIFIED
Adioro Soetojo, NIDN0010085102UNSPECIFIED
Soegeng Wahluyo, NIDN. 0010115405UNSPECIFIED
Indri Safitri Mukono, NIDN. 0014065303UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 26 Aug 2019 02:49
Last Modified: 30 Sep 2019 07:26
URI: http://repository.unair.ac.id/id/eprint/85747
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