Effect of Lactobacillus plantarum IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children

Alpha Fardah Athiyyah, 090970140 and Herwina Brahmantya and Stephani Dwiastuti and Andy Darma and Dwiyanti Puspitasari and Dominicus Husada, 091170114 and Reza Ranuh and Anang Endaryanto, 090415480 D and Ingrid Surono and Subijanto Marto Sudarmo (2019) Effect of Lactobacillus plantarum IS-10506 on blood lipopolysaccharide level and immune response in HIV-infected children. Iranian Journal of Microbiology, 11 (2). pp. 137-144. ISSN 20083289

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Official URL: http://ijm.tums.ac.ir/index.php/ijm/article/view/2...


Background and Objectives: HIV enteropathy may cause disruption of the intestinal barrier, leading to a loss of CD4+ T cells, increased intestinal permeability, and microbial translocation. Lactobacillus plantarum IS-10506 has the ability to improve gut barrier function. This study investigated the effect of L. plantarum IS-10506 on a number of biomarkers of enteropathy-related damage in HIV-infected paediatric patients undergoing antiretroviral therapy (ARV). Materials and Methods: A randomized, double-blind, placebo-controlled study was conducted on 2-18 year-old children, diagnosed as HIV infected according to the WHO 2007 criteria who had received ARV for ≥ 6 months. Subjects were excluded if ARV therapy was discontinued or the patients took probiotics ≥ 2 weeks prior to the study or during the study period. Subjects were randomized into a probiotic group and placebo group. The probiotic group received L. plantarum IS-10506 2.86 × 1010 cfu/day for 6 days. Blood lipopolysaccharide (LPS) level, serum CD4+ T cell count, serum CD8+ T cell count, CD4+/CD8+ T cell ratio, and faecal sIgA level were assessed as biomarkers. Results: Twenty-one subjects completed this study. The blood LPS level decreased significantly in the probiotic group (p = 0.001). There was no significant difference in absolute CD4+ T cell count, percent CD4+ cells, absolute CD8+ T cell count, CD4+/CD8+ T cell ratio, or faecal sIgA. No serious adverse events were reported. Conclusion: The probiotic L. plantarum IS-10506 reduced the blood LPS level but showed no effect on the humoral mucosa and systemic immune response in HIV-infected children undergoing ARV therapy.

Item Type: Article
Uncontrolled Keywords: Probiotics, Lactobacillus plantarum IS-10506, HIV infected children, Blood lipopolysaccharide, Immune responses
Subjects: R Medicine > R Medicine (General) > R5-920 Medicine (General)
R Medicine > RJ Pediatrics
R Medicine > RJ Pediatrics > RJ101 Child Health. Child health services
Divisions: 01. Fakultas Kedokteran > Ilmu Kesehatan Anak
Alpha Fardah Athiyyah, 090970140UNSPECIFIED
Herwina BrahmantyaUNSPECIFIED
Stephani DwiastutiUNSPECIFIED
Dwiyanti PuspitasariUNSPECIFIED
Dominicus Husada, 091170114UNSPECIFIED
Anang Endaryanto, 090415480 Danang.endaryanto@fk.unair.ac.id
Subijanto Marto Sudarmosubijantoms@gmail.com
Depositing User: hanif kurniawan
Date Deposited: 12 Aug 2019 06:14
Last Modified: 12 Aug 2019 06:14
URI: http://repository.unair.ac.id/id/eprint/85748
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