Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy

Achmad Dzihan Shaghiera and Prihartini Widiyanti and Helmy Yusuf, NIDN. 0015077901 (2018) Synthesis and Characterization of Injectable Hydrogels with Varying Collagen–Chitosan–Thymosin β4 Composition for Myocardial Infarction Therapy. Journal of Functional Biomaterials, 9 (2). pp. 1-11. ISSN 2079-4983

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Official URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC60233...

Abstract

Thirty percent of global mortalities are caused by cardiovascular disease, and 54% of the aforementioned amount is instigated by ischemic heart disease that triggered myocardial infarction. Myocardial infarction is due to blood flow cessation in certain coronary arteries that causes lack of oxygen (ischemia) and stimulates myocardial necrosis. One of the methods to treat myocardial infarction consists in injecting cells or active biomolecules and biomaterials into heart infarction locations. This study aimed to investigate the characteristics of a collagen–chitosan-based hydrogel with variations in its chitosan composition. The prepared hydrogels contained thymosin �4 (T�4), a 43-amino acid peptide with angiogenic and cardioprotective properties which can act as a bioactive molecule for the treatment of myocardial infarction. A morphological structure analysis showed that the hydrogels lacked interconnecting pores. All samples were not toxic on the basis of a cytotoxicity test. A histopathological anatomy test showed that the collagen–chitosan–thymosin �4 hydrogels could stimulate angiogenesis and epicardial heart cell migration, as demonstrated by the evaluation of the number of blood vessels and the infiltration extent of myofibroblasts.

Item Type: Article
Uncontrolled Keywords: myocardial infarction; hydrogel; collagen; chitosan; thymosin β4
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Achmad Dzihan ShaghieraUNSPECIFIED
Prihartini WidiyantiUNSPECIFIED
Helmy Yusuf, NIDN. 0015077901UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 19 Aug 2019 02:30
Last Modified: 19 Aug 2019 02:30
URI: http://repository.unair.ac.id/id/eprint/85767
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