THE MECHANISM OF ALPHA LIPOIC ACID ON REDUCING THE MDA LEVEL AND MCP-1 EXPRESSION IN ENDOTHELIAL DYSFUNCTION OF HYPERCHOLESTEROLEMIA RAT (RATTUS NORVEGICUS) MODEL

Dewi Perwito Sari, 050710291 and Imam Susilo, NIDN. 0010086503 and Junaidi Khotib, NIDN. 0022107001 (2016) THE MECHANISM OF ALPHA LIPOIC ACID ON REDUCING THE MDA LEVEL AND MCP-1 EXPRESSION IN ENDOTHELIAL DYSFUNCTION OF HYPERCHOLESTEROLEMIA RAT (RATTUS NORVEGICUS) MODEL. Folia Medica Indonesiana, 52 (3). pp. 154-159. ISSN 2355-8393

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Official URL: https://e-journal.unair.ac.id/FMI/article/view/544...

Abstract

Endothelial dysfunction is an initial condition of atherosclerosis and other vascular diseases where one of the risk factors is hypercholesterolemia. Blood cholesterol levels is associated with an increase in the production of reactive oxygen species (ROS). The increasing of ROS production can cause increased oxidative stress which in turn resulting in endothelial dysfunction. Alpha lipoic acid (ALA) is one of the antioxidant compound that has been developed and studied. In this study we found that the use of ALA in Rattus norvegicus rats signifficantly lower the total cholesterol levels at dose 60 mg/kgBW (p=0.020). ALA also inhibit the expression of Monocyte Chemoattractant Protein-1 (MCP-1) at dose 60 mg/kgBW (p=0.044) and reduces the formation of Malondialdehyde (MDA) at dose 120 mg/kgBW (p=0.009), which is the initial stage of the atherogenic development and prognosis of events, thus, ALA can reduce the risk of further damage to the endothelium.

Item Type: Article
Uncontrolled Keywords: hypercholesterolemia; endothelial dysfunction; MDA; MCP-1; alpha lipoic acid
Subjects: R Medicine > R Medicine (General)
R Medicine > RB Pathology
Divisions: 01. Fakultas Kedokteran > Patologi Anatomi
Creators:
CreatorsNIM
Dewi Perwito Sari, 050710291UNSPECIFIED
Imam Susilo, NIDN. 0010086503imam-susilo@fk.unair.ac.id
Junaidi Khotib, NIDN. 0022107001UNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 20 Aug 2019 03:53
Last Modified: 20 Aug 2019 03:53
URI: http://repository.unair.ac.id/id/eprint/85843
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