Hendrik Setia Budi and Eha Renwi Astuti (2019) The MMP-2, MMP-9 Expression and Collagen Density of the Ambonese Banana Stem Sap Administration on Wound Healing. Journal of International Dental and Medical Research, 12 (2). pp. 492-497. ISSN 1309-100X

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Abstract

Matrix metalloproteinases (MMP) will degrade of the extracellular matrix and proteins, including collagen, elastin, gelatin, matrix glycoproteins and proteoglycans. It affects the BMP in the process of differentiation and new bone tissue remodeling. Ambonese banana (Musa paradisiaca var. Sapientum) have potency to accelerate wound healing throught platelet derived growth factor (PDGF-BB) signaling. The research was conducted to prove the role of ambonese banana stem sap gel (GEGPA) on the MMP-2 and MMP-9 expression affected to collagen density of tooth extraction wound healing. This study used 24 male wistar rats were divided into 2 groups: one is a control without being treated, and the other one is a group GEGPA dose 60 mg in 4% Hydroxypropyl Methylcellulose. All groups were examined for the expression of MMP-2, MMP-9, and collagen density in alveolar socket areas on day 7 and 14. The results showed there were significant differences in the expression of MMP-2, MMP-9, and collagen density in the alveolar socket healing between day 7 and 14 (p=0.00 and p=0.00). There was a strong correlation p=0.963 between the inhibition of MMP-2, MMP-9 and the increasing of collagen density. It is concluded that GEGPA increases collagen density on wound healing of tooth extraction through inhibition MMP-2 and MMP-9.

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