Preparation and Physical Characterization of Andrographolide-Chitosan-Alginate Microparticles prepared by Ionic Gelation–Freeze Drying

Sari, Retno and Tunggadewi, Sandra and Paramanandana, Abhimata and Yusuf, Helmy (2019) Preparation and Physical Characterization of Andrographolide-Chitosan-Alginate Microparticles prepared by Ionic Gelation–Freeze Drying. Research Journal of Pharmacy and Technology, 12 (2). pp. 553-557. ISSN 0974360X

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Official URL: http://rjptonline.org/AbstractView.aspx?PID=2019-1...

Abstract

This study aimed to determine the effect of alginate concentration on physical characterization (morphology, physical state, and encapsulation efficiency) of andrographolide-chitosan-alginate microparticles prepared by ionic gelation- freeze drying method. Andrographolide-chitosan-alginate microparticles were produced with various amount of alginate by ionic gelation method using tripholyphospate (TPP) as crosslinker and maltodextrin as a lyoprotectant. The physical characteristics were evaluated using Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectrophotometer (FT-IR), Differential Thermal Analyzer (DTA), Powder X-ray diffractrometer (PXRD), drug content was evaluated using High Pressure Liquid Chromatography (HPLC). The results showed that andrographolide crystallinity changed after encapsulated inside the microparticles supported by changes in IR spectra, and melting point. Furthermore, increased alginate concentration showed rougher surface morphology. The amount of alginate affected the characteristics of the andrographolide-chitosan-alginate microparticles by altering the crystallinity and lowering melting point. The highest encapsulation efficiency shown by microparticles with 0.5% alginate.

Item Type: Article
Uncontrolled Keywords: Microparticles, andrographolide, chitosan, alginates, ionic gelation.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Sari, RetnoUNSPECIFIED
Tunggadewi, SandraUNSPECIFIED
Paramanandana, AbhimataUNSPECIFIED
Yusuf, HelmyUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 20 Aug 2019 07:01
Last Modified: 20 Aug 2019 07:01
URI: http://repository.unair.ac.id/id/eprint/85917
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