Chaterina Diyah Nanik and Wisnu Setyari Juliastuti and Hendrik Setia Budi (2009) Efek hepatoprotektor sari buah wortel (Daucus carota L.) pada mencit yang diinduksi parasetamol. Oral Biologi Dental Journal, 1 (1). ISSN 1979-8814

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Abstract

The used of paracetamol in high dose or in a long term could cause the hepatic damaged. Paracetamol at dose of 400mg/kg body weight produced liver damaged in mice as manifested by the risemin serum level of Glutamate Oxaloacetate Transaminase (SGOT) and Glutamate Pyruvate Transaminase (SGPT). The aim of this research was to investigate the hepatoprotective effect of carrot juice against paracetamol induced hepatic damaged in mice. Thirty five male Swiss Webster,Balb/C mice were randomly divided into five group samples : the negative control group, the positive control group and the three different dose of carrot juice groups (5,10 and 20 ml/kg body weight). Kruskal-Wallis test was employed to analyze the data. The result showed that the carrot juice had the hepatoprotective effect against paracetamol induced hepatic damaged in mice. Pretreatment with carrot juice at dose of 20 ml/kgBW prevented paracetamol induced rise in SGOT and SGPT better than 5 and 10ml/kgBW doses. The higher dose of carrot juice had the better potency against the hepatotoxicity.

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