Metformin induced autophagy in diabetes mellitus – Tuberculosis co-infection patients: A case study

Bernadette Dian Novita Dewi, NIM011317017307 and Mulyohadi Ali and Agung Pranoto, NIDN. 0004015605 and Endang Isbandiati Soediono and Ni Made Mertaniasih, NIDN. 0007035703 (2019) Metformin induced autophagy in diabetes mellitus – Tuberculosis co-infection patients: A case study. Indian Journal of Tuberculosis, 66. pp. 64-69. ISSN 0019-5707

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Official URL: https://www.sciencedirect.com/science/article/pii/...

Abstract

Metformin (MET) is a potential combination drug to elevate anti-TB efficacy. However, the clinical effect, especially smear reversion, during metformin applied with anti-tuberculosis and insulin in patients with type 2 DM newly TB co-infection were remain unknown. An observational clinical study was done in DM newly TB co-infection outpatients at Surabaya Paru Hospital. This study evaluated MET therapy, at least 2 months, accompanying with insulin and anti-TB regimens and compared to comparison group. The smear, microtubule-associated Protein1 Light Chain 3B (MAP1LC3B) level, as the presentation of autophagy, Superoxide Dismutase (SOD) level, Interferon (IFN)-γ and Interleukin (IL)-10 levels were evaluated twice. From 42 participants in this study, 22 participants of observation group that received additional MET therapy, 100% had sputum smear reversion after 2-months intensive phase of anti-TB therapy. Whereas 25% of 20 participants of comparison group did not undergo reversion inserts sputum smear. As conclusion, MET has the potential of being an additive combination therapy to enhance the bactericidal effect of anti-TB on DM-TB coinfection patients. Metformin enhances the effects of anti-TB and insulin therapy in increasing the smear reversion by increasing autophagy.

Item Type: Article
Uncontrolled Keywords: Type 2 diabetes mellitus-tuberculosis co-infection patients, Metformin, AFB smear reversion, Autophagy
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine
R Medicine > RC Internal medicine > RC306-320.5 Tuberculosis
Divisions: 01. Fakultas Kedokteran > Ilmu Penyakit Dalam
Creators:
CreatorsNIM/NIDN
Bernadette Dian Novita Dewi, NIM011317017307UNSPECIFIED
Mulyohadi AliUNSPECIFIED
Agung Pranoto, NIDN. 0004015605agung-p@fk.unair.ac.id
Endang Isbandiati SoedionoUNSPECIFIED
Ni Made Mertaniasih, NIDN. 0007035703UNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 02 Oct 2019 06:44
Last Modified: 02 Oct 2019 06:44
URI: http://repository.unair.ac.id/id/eprint/86088
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