Clinical Outcome of Patients with Diffuse Axonal Injury Receiving Adrenocorticotropin Analogue at Dr. Soetomo Hospital

Joni Wahyuhadi, NIDN. 8885900016 and Pandu Wicaksono, 07051760 and Hari Basuki (2018) Clinical Outcome of Patients with Diffuse Axonal Injury Receiving Adrenocorticotropin Analogue at Dr. Soetomo Hospital. Folia Medica Indonesiana, 54 (3). pp. 222-227. ISSN 2355-8393

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Official URL: https://e-journal.unair.ac.id/FMI/article/view/100...

Abstract

Brain traumatic injury (BTI) is one of the causes of death and disability worldwide that affects people regardless of sex, age, income and social status, race, or nationality. In patients with brain traumatic injury, one of the problems that occurs is Diffuse Axonal Injury (DAI) that can produce a direct clinical effect, leading to coma and death. Adrenocorticotropin analogues (ACTH) is one of neuroprotective therapy in brain injury. The aim of this study was to analyze the effect of ACTH analogue on the clinical output (Glasgow Outcome Score/GOS and Bartle Index) in patients with DAI at hospital discharge, 3 months and 6 months post-treatment. This study revealed that ACTH analogue administration resulted in higher GOS and Barthel Index scores than that in control. Further study will required with other variables, such as cognitive and motor examination, and some biomarkers can also be examined serially. Brain traumatic injury (BTI) is one of the causes of death and disability worldwide that affects people regardless of sex, age, income and social status, race, or nationality. In patients with brain traumatic injury, one of the problems that occurs is Diffuse Axonal Injury (DAI) that can produce a direct clinical effect, leading to coma and death. Adrenocorticotropin analogues (ACTH) is one of neuroprotective therapy in brain injury. The aim of this study was to analyze the effect of ACTH analogue on the clinical output (Glasgow Outcome Score/GOS and Bartle Index) in patients with DAI at hospital discharge, 3 months and 6 months post-treatment. This study revealed that ACTH analogue administration resulted in higher GOS and Barthel Index scores than that in control. Further study will required with other variables, such as cognitive and motor examination, and some biomarkers can also be examined serially.

Item Type: Article
Uncontrolled Keywords: Diffuse Axonal Injury, adrenocorticotropin, Glasgow Outcome Score, Barthel Index
Subjects: R Medicine > R Medicine (General)
R Medicine > RD Surgery
Divisions: 01. Fakultas Kedokteran > Ilmu Bedah Saraf
Creators:
CreatorsNIM/NIDN
Joni Wahyuhadi, NIDN. 8885900016joniwahyuhadi@fk.unair.ac.id
Pandu Wicaksono, 07051760UNSPECIFIED
Hari BasukiUNSPECIFIED
Depositing User: hanif kurniawan
Date Deposited: 04 Sep 2019 07:46
Last Modified: 04 Sep 2019 07:46
URI: http://repository.unair.ac.id/id/eprint/86155
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