Anti-Inflammatory Evaluation of NLC (Nanostructured Lipid Carriers) Meloxicam In-Vivo

Widyaningrum I and Dewi Melani Hariyadi and Esti Hendradi (2017) Anti-Inflammatory Evaluation of NLC (Nanostructured Lipid Carriers) Meloxicam In-Vivo. International Journal of Drug Delivery Technology, 7 (4). pp. 327-331. ISSN 0975-4415

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Official URL: http://impactfactor.org/PDF/IJDDT/7/IJDDT,Vol7,Iss...

Abstract

Objective: The aim of this research study was to investigate the anti-inflammatory effect of NLC meloxicam. NLC contains solid and liquid lipid. Monostearin as solid lipid and Miglyol 808 as liquid lipid. Methods : NLC meloxicam was repared using emulsification methodwith three different lipid ratio. . NLC meloxicam was prepared and characterized for measuring the pH, viscocity, particle size, and entrapment efficiency. The rat paw edema test was performed to evaluate the antiinflammatory activity of three formulations NLC meoxicam. Results : based on research result shows that the smaller the solid lipid concentrations, particle size is the larger, the greater viscosity, thus increasing occlusive NLC to the skin. The third formula hasthe greatest solid lipid concentration shows the smallest AUC value but once in a statistical test known to be significantly different from the three formulas. Conclusions : NLC meloxicam showed that it had anti-inflammatoryeffectiveness.

Item Type: Article
Uncontrolled Keywords: NLC, meloxicam, antiinflammatory, paw edema
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM
Widyaningrum IUNSPECIFIED
Dewi Melani HariyadiNIDN0026027801
Esti HendradiNIDN0014115703
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 10 Sep 2019 01:36
Last Modified: 30 Dec 2019 05:10
URI: http://repository.unair.ac.id/id/eprint/86184
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