Hispathology of Coronary artery of male rat (Ratus Norvegicus) With high fat diet after being given ethanol extract of Indian acalypha (Acalipha indica. L)

Rochmah Kurnijasanti and D. Winarti and Retno Sri Wahjuni and Kuncoro Puguh Santoso and Setyabudi and Moh. Sukmanadi and Rahmi Sugihartuti and Ratna Damayanti and Nove Hidajati and Kadek Rachmawati and Sri Agus Sudjarwo (2017) Hispathology of Coronary artery of male rat (Ratus Norvegicus) With high fat diet after being given ethanol extract of Indian acalypha (Acalipha indica. L). The Veterinary Medicine International Conference 2017. pp. 241-251. ISSN 2413-0877

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Abstract

This research aims to know the effect of ethanol extract of Indian acalypha (Acalipha indica L) to histopathology of coronary artery of male rat (Ratus norvegicus) with high fat diet. Twenty male rats (Rattus Norvegicus) males aged 3-5 months with mean weight 200 grams were divided into 5 groups and 4 replications. Group 1 (negative control) was only given standard feed and distilled on ad libidum. Four groups (Positive control, Treatment 1, 2 and 3) were made hypercholesterolaemia by administering 1 mL peroral pork oil for 56 days. On day 14, the cholesterol levels were checked. After hypercholesterolaemia, from day 15 to day 56, each group was given ethanol extract of Indian acalypha peroral with a dose of 200 g / kg BW (P1), 400 g / kg BW (P2) and 800 g / kgBW (P3), whereas the positive control groups were not given ethanol extract of Indian acalypha. On day 57, the dying rat was dissected for the removal of the cardiac organ and the making of coronary artery histopathological preparation. Data on histopathologic observation of coronary artery were analyzed by the KruskalWallis test, and if there was a significant difference between treatment groups (p<0.05), then it continued with the Mann-Whitney test. The results showed that in infiltration of fat cells and endothelial cells that experienced damage treatment P1, P2, and P3 which were given extracts of Indian acalypha experienced decrease compared to positive control treatment groups. The result of statistical test of fat cells and endothelial cells in the coronary artery that experienced damage showed significant differences between treatment groups (p <0.05), whereas in the statistical test of coronary artery foam cells showed no significant differences between treatment groups (P> 0, 05). From the research, it can be concluded that ethanol extract of Indian acalypha (Acalipha indica L) can improve histopathology coronary artery of rat fed high fat diet

Item Type: Article
Uncontrolled Keywords: Hispathology; Coronary artery; Ratus Norvegicus Acalipha indica. L
Subjects: S Agriculture > SF Animal culture > SF405.5-407 Laboratory animals
S Agriculture > SF Animal culture > SF600-1100 Veterinary medicine > SF811-909 Veterinary medicine of special organs, regions, and systems
Divisions: 06. Fakultas Kedokteran Hewan > Ilmu Kedokteran Hewan Dasar
Creators:
CreatorsNIM
Rochmah KurnijasantiNIDN0019077004
D. WinartiUNSPECIFIED
Retno Sri WahjuniNIDN0006035602
Kuncoro Puguh SantosoNIDN0015106601
SetyabudiNIDN0029015405
Moh. SukmanadiNIDN0006086807
Rahmi SugihartutiNIDN0021026702
Ratna DamayantiNIDN0026096603
Nove HidajatiNIDN0015116501
Kadek RachmawatiNIDN0025076801
Sri Agus SudjarwoNIDN0004095603
Depositing User: Nn Erna Dwi Indriyani
Date Deposited: 16 Sep 2019 04:25
Last Modified: 26 Feb 2020 02:11
URI: http://repository.unair.ac.id/id/eprint/86205
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