In Vivo Neuroprotective Activity of Erythropoietin-Alginate Microspheres at Different Polymer Concentrations

Melani Hariyadi, Dewi and Rahmadi, Mahardian and Rahman, Zakaria (2018) In Vivo Neuroprotective Activity of Erythropoietin-Alginate Microspheres at Different Polymer Concentrations. Asian Journal of Pharmaceutics, 12 (4). pp. 255-260. ISSN 1998-409X

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Aim: The aim of this study was to evaluate in vivo neuroprotectant activity of erythropoietin-alginate microspheres with different concentrations to modify release to reduce the administration frequency of erythropoietin. Materials and Methods: Sodium alginate and CaCl were used to produce microspheres using aerosolization technique and erythropoietin as model. Balb/c-strain mice (Mus musculus) were used to study in vivo activity in terms of locomotor activity and glutathione peroxidase (GSHPx) activity as well as percentage of reticulocytes. Results and Discussion: Erythropoietin-alginate microspheres demonstrated neuroprotectant activity such as locomotor activity and GSHPx activity compared to erythropoietin alone and blank microspheres. Increased polymer concentrations (1–3%), however, did not have a significant effect on changes of the effectiveness of the activity of microspheres. Interestingly, these results also showed that erythropoietin-alginate microspheres which contain only 5000 units produced a high percentage of reticulocytes. Conclusion: The study indicates that erythropoietin-alginate microspheres showed the potential activity of erythropoietin-alginate microspheres although in low concentration. Increased concentrations of polymers showed similar effects in locomotors activity and GSHPx enzyme activity as parameters of neuroprotectant activity.

Item Type: Article
Uncontrolled Keywords: Alginate microspheres, erythropoietin, glutathione peroxidase, in vivo activity, neuroprotectant
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Melani Hariyadi, DewiUNSPECIFIED
Rahmadi, MahardianUNSPECIFIED
Rahman, ZakariaUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 10 Sep 2019 01:14
Last Modified: 10 Sep 2019 01:59
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