Characterization and Release of Ibuprofen in Proniosome System (Ibuprofen-Span 60-Cholesterol)

Purwanti, Tutiek and Melani Hariyadi, Dewi and Silvia, Corry (2018) Characterization and Release of Ibuprofen in Proniosome System (Ibuprofen-Span 60-Cholesterol). International Journal of Drug Delivery Technology, 8 (2). pp. 103-106. ISSN 0975-4415

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Abstract

The aim of this research was to determine influence of proniosome system which consists of ibuprofen-span 60cholesterol with molar ratio of 2:1:0.75. The proniosome system was made by Coacervation Phase Separation Method, using ethanol 96% as solvent and glycerol 0.1% as aqueous phase. There were two formulas in this research formula I was ibuprofen non proniosome in HPMC gel base and formula II was ibuprofen proniosome in HPMC gel base. Characterization of formulas included organoleptic and pH of ibuprofen gel. Drug release was determined using diffusion cell and cellophane membrane in phosphate buffer pH 6.0 ± 0.05 at temperature 32 ± 0.5 o C for 7 hours. The drug release (flux) of ibuprofen from formula I and II were 28.3067 ± 3.0852 µg/cm 2 /min ½ and 23.1900 ± 1.7658 µg/cm 2 /min ½ , respectively. The statistical result using independent sample T-test on degree of confident of 95% (α = 0.05) concluded that there was significant value of their fluxs. Research result revealed that release of ibuprofen proniosome system was lower than ibuprofen nonproniosome system in HPMC 4000 gel base.

Item Type: Article
Uncontrolled Keywords: proniosome, ibuprofen, drug release
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Purwanti, TutiekUNSPECIFIED
Melani Hariyadi, DewiUNSPECIFIED
Silvia, CorryUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 10 Sep 2019 01:18
Last Modified: 10 Sep 2019 01:18
URI: http://repository.unair.ac.id/id/eprint/86277
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