The Performance of Nanostructured Lipid Carrier (NLC) Incorporated Transdermal Patch Coenzyme Q10: Effect of Lipid Ratio as Drug Reservoir and HPMC 606 as Rate Controlling Membrane

Esti Hendradi, NIDN. 0014115703 and Isnaeni, NIDN. 0013015603 and Raudatul Patimah (2018) The Performance of Nanostructured Lipid Carrier (NLC) Incorporated Transdermal Patch Coenzyme Q10: Effect of Lipid Ratio as Drug Reservoir and HPMC 606 as Rate Controlling Membrane. International Journal of Pharma Research and Health Sciences, 6 (5). pp. 2796-2800. ISSN 2348-6465

[img] Text (FULTEXT)
C-19.pdf

Download (3MB)
[img] Text (SIMILARITY)
Result Bukti C-19.pdf

Download (2MB)
[img] Text (PEER REVIEW)
Rev C-19.pdf

Download (1MB)
Official URL: http://pharmahealthsciences.net/pdfs/volume6-issue...

Abstract

Coenzyme Q10 is a strong antioxidant. Coenzyme Q10 can improve cellular dynamics inhuman body and playan effective role in preventing skin aging, keratinization and DNAoxidative. Coenzyme Q10 NLC system with different lipid ratio 70:30 (cetyl palmitate andalpha tocopheryl acetate) used as drug reservoir dan hydroxypropyl methylcellulose 606(HPMC 606) as rate controlling membrane. NLC coenzyme Q10 as drug reservoir wereprepared using high shear homogenization method. Transdermal patch was usingmembranetype with HPMC 606 as rate controlling membrane. This research was investigatethe effect of concentration of HPMC 10%, 15% and 20% on the characteristics coenzyme Q10transdermal patch. The prepared transdermal patches were evaluated for thickness, weightvariation, moisture content, drug content and drug homogenity which were found to 1.98 ±0.003 mm, 1.422 ± 0.003 g, 8.441 ± 0.077 %, 96.90± 0.92 and 97.75 ± 1.78 %, respectively.All independent variables had no significant effect on the dependent variables (p-values>0.05) usingone way ANOVA, except the weight and moisture content patches.

Item Type: Article
Uncontrolled Keywords: Coenzyme Q10, Hydroxypropyl methyl cellulose606, Nanostructured lipid carrier, Characteristic of transdermal patch
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsEmail
Esti Hendradi, NIDN. 0014115703UNSPECIFIED
Isnaeni, NIDN. 0013015603UNSPECIFIED
Raudatul PatimahUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 12 Sep 2019 06:34
Last Modified: 12 Sep 2019 06:34
URI: http://repository.unair.ac.id/id/eprint/86312
Sosial Share:

Actions (login required)

View Item View Item