Preparation and characterization of BSA-loaded Chitosan microspheres

Esti Hendradi, NIDN. 0014115703 and Retno Sari, NIDN. 0008106303 and Rifka Anggraini Anggai (2018) Preparation and characterization of BSA-loaded Chitosan microspheres. Health Notions, 2 (9). pp. 930-934. ISSN 2580-4936

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Proteins are unstable molecules because of their complex structure and easily degraded by enzymatic systems. Biodegradable microspheres have been used in protein delivery system. Bovine serum albumin was chosen as a model protein. Chitosan/tripolyphosphate microparticles have already been used to encapsulated BSA. The aim of this work was to microencapsulate these protein-CS/TPP by ionic gelation and freeze-drying. The morphology, particle size, and encapsulation efficiency of the prepared microspheres were investigated. The results revealed that the microspheres exhibited good sphericity with ranged in size from 2.25 to 2.73 µm. The study found that the moisture content of microspheres was 2.8%, the encapsulation efficiency of BSA in CS-TPP microspheres ranged from 88.14 to 96.25%. The results suggested that iontoropic gelation method will be an effective method for fabricating chitosan microspheres for delivery of protein.

Item Type: Article
Uncontrolled Keywords: Microspheres, BSA, Ionic Gelation
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Esti Hendradi, NIDN. 0014115703UNSPECIFIED
Retno Sari, NIDN. 0008106303UNSPECIFIED
Rifka Anggraini AnggaiUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 13 Sep 2019 00:25
Last Modified: 13 Sep 2019 00:25
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