Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model AntiInflammatory Drug

Esti Hendradi, NIDN. 0014115703 and Isnaeni, NIDN. 0013015603 and Rifaatul Mahmudah (2018) Optimation Ca-Alginate Beads as Drug Reservoir in the Patch System for Model AntiInflammatory Drug. Health Notions, 2 (9). pp. 946-951. ISSN 2580-4936

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Official URL: http://heanoti.com/index.php/hn/article/view/hn209...


The aim of this study was to optimize the use of Ca-Alginates beads as a drug reservoir in the patch system with and without freeze-drying process. Meloxicam, an anti-inflammatory non-steroidal drug, was used as a drug model. Ca-alginate beads were prepared by ionic gelation method using polymer alginate and cross-linker CaCl2. The beads were evaluated for its melting temperature, FTIR spectra, and entrapment efficiency. The FTIR study showed the loss of guluronic peaks of alginate caused by a cross-linking process with Ca2+, characteristics peaks of meloxicam still appeared indicating the compatibility of the drug with the polymers used. The using Ca-alginate beads without freeze-drying process as a drug reservoir resulted in a very wet patch that was difficult to dry, cracked surface, and pharmaceutically not acceptable. Meanwhile, patch using Ca-alginate beads with the freezedrying process as a drug reservoir demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to giving uniformity in the drug content.

Item Type: Article
Uncontrolled Keywords: Ca-alginate, Freeze-dry, Patch, Meloxicam, Transdermal delivery
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Esti Hendradi, NIDN. 0014115703UNSPECIFIED
Isnaeni, NIDN. 0013015603UNSPECIFIED
Rifaatul MahmudahUNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 13 Sep 2019 00:32
Last Modified: 13 Sep 2019 00:32
URI: http://repository.unair.ac.id/id/eprint/86314
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