Physical Characteristics of Reservoir Type Patch Using Nanostructured Lipid Carriers (NLC) as Drug Resevoir, HPMC 606 as Rate Controlling Membrane and Meloxicam Drug Model

Esti Hendradi and Asri Darmawati and Adek Bela Anggraeni (2018) Physical Characteristics of Reservoir Type Patch Using Nanostructured Lipid Carriers (NLC) as Drug Resevoir, HPMC 606 as Rate Controlling Membrane and Meloxicam Drug Model. World Journal of Pharmacy and Pharmaceutical Sciences, 7 (11). pp. 71-78. ISSN 2278 – 4357

[img] Text (FULLTEXT)
C-22 fix.pdf

Download (5MB)
[img] Text (SIMILARITY)
Result Bukti C-22.pdf

Download (2MB)
[img] Text (Peer Review)
C-22 Reviewer.pdf

Download (1MB)
Official URL: http://www.wjpps.com/wjpps_controller/abstract_id/...

Abstract

The purpose of this research work was to create a meloxicam patch transdermal drug delivery system using Nanostructured Lipid Carriers (NLC) as drug reservoir and Hydroxy Propyl Methyl Cellulose (HPMC) as rate controlling membrane. Meloxicam, an antiinflammatory non-steroidal drugs, was used as a drug model. The NLC was done by using high-shear homogenization method. In this formulation, monostearin and alpha-tocopherol were used as lipid matrix. The transdermal patches of meloxicam were prepared by using different percentages of rate controlling membrane. NLC Meloxicam was dispersed into 1 ml rate controlling solution and spread over the backing layer followed by drying at room temperature.The patches were evaluated for physical appearance, weight variation, moisture content, drug content uniformity and morphology. The patches demonstrated satisfactory characteristics with minimum weight variation among the patches that lead to give uniformity in the drug content.

Item Type: Article
Uncontrolled Keywords: Patch, meloxicam, NLC, transdermal.
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Creators:
CreatorsNIM/NIDN
Esti HendradiNIDN0014115703
Asri DarmawatiNIDN0028125608
Adek Bela AnggraeniNIM051614153007
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 13 Sep 2019 00:43
Last Modified: 06 Jan 2020 09:59
URI: http://repository.unair.ac.id/id/eprint/86315
Sosial Share:

Actions (login required)

View Item View Item