Transdermal patch loading diclofenac sodium for anti inflammation therapy using rat paw oedema model

P. Christanto and Isnaeni, NIDN. 0013015603 and Andang Miatmoko, NIDN. 0002108503 and Esti Hendradi, NIDN. 0014115703 (2017) Transdermal patch loading diclofenac sodium for anti inflammation therapy using rat paw oedema model. In: Proceedings of The 17th Asian Conference On Clinical Pharmacy (ACCP 2017): Unity in Diversity and the Standardisation of Clinical Pharmacy Services. CRC Press, London, pp. 10-18. ISBN 978-1-138-08172-7

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The anti-inflammatory effect of transdermal delivery of a diclofenac sodium patch was evaluated. The patch matrix consists of ethyl cellulose N-20 and polyvinyl pyrrolidone K-30 to control the drug release. In this study, the patches were prepared with ethyl cellulose N-20 (EC-N20) and polyvinylpyrrolidone K-30 (PVP K-30) at weight ratio of 6:4 and 7:3 for EC/PVP-6/4 and EC/PVP-7/3 patches, respectively. The anti-inflammatory effect was determined by evaluating the swelling of rat’s paw oedema that was induced with 1% carrageenan suspension. The results showed that the high concentration of PVP K-30 resulted in less rigid patch with pore structures. In addition, it improved the antiinflammatory effect of diclofenac sodium resulted in higher efficacy of EC/PVP-6/4 than that of EC/PVP-7/3. There were no significant differences on drug stability observed for both formulations. It can be concluded that controlling diclofenac sodium released from patch using PVP K-30 could give benefits for anti-inflammation therapy.

Item Type: Book Section
Subjects: R Medicine
R Medicine > RS Pharmacy and materia medica
Divisions: 05. Fakultas Farmasi
Isnaeni, NIDN. 0013015603UNSPECIFIED
Andang Miatmoko, NIDN. 0002108503UNSPECIFIED
Esti Hendradi, NIDN. 0014115703UNSPECIFIED
Depositing User: Mr M. Fuad Sofyan
Date Deposited: 11 Sep 2019 07:45
Last Modified: 11 Sep 2019 07:45
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