Sri Puji Astuti Wahyuningsih, NIDN. 0021026604 and Manikya Pramudya and Intan Permata Putri and Dwi Winarni, NIDN. 0011076505 and Nadyatul Ilma Indah Savira and Win Darmanto, NIDN. 0016066103 (2018) Crude Polysaccharides from Okra Pods (Abelmoschus esculentus) Grown in Indonesia Enhance the Immune Response Due to Bacterial Infection. Advances in Pharmacological Sciences, 2018. pp. 1-7. ISSN 1687-6334

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Abstract

Okra pods were widely consumed by Indonesians to maintain health. ,e aim of this study was at investigating the potential of crude polysaccharides from okra pods on immune response in mice infected with Staphylococcus aureus. ,irty male Balb/C mice were divided into six groups: normal control, negative control, and treatment groups (administration of crude polysaccharides at doses of 25, 50, 75, and 100 mg/kg). Crude polysaccharides were administrated for fourteen days. Furthermore, mice were exposed to S. aureus at the fifteenth day. Two weeks after the end of treatment, the parameters were measured. ,is study showed that crude polysaccharides at a dose of 75 and 100 mg/kg improved phagocytic activity, spleen index, and splenocytes proliferation. Rising of TNF-α levels was shown in groups treated with crude polysaccharides at doses of 25, 50, and 100 mg/kg. All treatment groups showed a decreasing level of IL-17. Crude okra polysaccharides also showed a slight increase in NK cells activity and IFN-c level. ,us, crude okra polysaccharides could act as an effective material to enhance immune response including phagocytic activity, spleen index, splenocytes proliferation, and control immune responses through cytokine production.

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