The Effect of Estrogen on Type 2 Collagen Levels in the Joint Cartilage of Post-Menopausal Murine Subjects

Bimo Sasono and Fedik Abdul Rantam, NIDN. 0010035907 and Heri Suroto, NIDN. 8802630017 and Hari Basuki Notobroto, NIDN. 0025066504 (2019) The Effect of Estrogen on Type 2 Collagen Levels in the Joint Cartilage of Post-Menopausal Murine Subjects. Journal of Hard Tissue Biology, 28 (3). pp. 245-250. ISSN 1341-7649

[img] Text (Full Text)
PAK HARI.pdf

Download (736kB)
Official URL: https://www.jstage.jst.go.jp/article/jhtb/28/3/28_...

Abstract

Cartilage degradation frequently occurs during the postmenopausal period due to a decrease in type 2 collagen and constitutes a condition affected by the level of estrogen in the body. The purpose of this study is to prove that such post-menopausal reductions in estrogen levels influence the type 2 collagen expression in cartilage. Oophorectomies were per-formed on 54 Rattus norvegicus subjects and each of which was subsequently assigned to one of six different groups. 17β-estradiol present in the blood of the subjects was examined by means of ELISA technique, while the expression of MMP-13 and type 2 collagen in their knee joint cartilage was assessed immunohistochemically. A significant post-oopho-rectomy decrease of 17β-estradiol was detected in subjects (p<0.05), while the expression of MMP-13 increased apprecia-bly (p<0.05) and a marked decrease in type 2 collagen expression occurred (p<0.05). The reduction in 17β-estradiol pro-moted an increase in the expression of MMP-13 and a decrease in type 2 collagen expression.

Item Type: Article
Uncontrolled Keywords: 17β-estradiol, MMP-13, Type 2 collagen
Subjects: R Medicine
Divisions: 10. Fakultas Kesehatan Masyarakat
Creators:
CreatorsNIM/NIDN
Bimo SasonoUNSPECIFIED
Fedik Abdul Rantam, NIDN. 0010035907UNSPECIFIED
Heri Suroto, NIDN. 8802630017UNSPECIFIED
Hari Basuki Notobroto, NIDN. 0025066504UNSPECIFIED
Depositing User: Tn Chusnul Chuluq
Date Deposited: 11 Sep 2019 01:42
Last Modified: 11 Sep 2019 01:42
URI: http://repository.unair.ac.id/id/eprint/86493
Sosial Share:

Actions (login required)

View Item View Item