PENGARUH TERAPI ORAL LETROZOLE TERHADAP PROFIL LIPID PASIEN KANKER PAYUDARA POST MENOPAUSE DENGAN ER+/PR+ (Penelitian Dilaksanakan di Instalasi Rawat Jalan Poli Hematologi-Onkologi RSU Haji Surabaya)

LENDY NUGROHO WISNU MURTI, 051715153009 (2019) PENGARUH TERAPI ORAL LETROZOLE TERHADAP PROFIL LIPID PASIEN KANKER PAYUDARA POST MENOPAUSE DENGAN ER+/PR+ (Penelitian Dilaksanakan di Instalasi Rawat Jalan Poli Hematologi-Onkologi RSU Haji Surabaya). Thesis thesis, Universitas Airlangga.

[img] Text (ABSTRAK)
TFK. 18-19 Mur p ABSTRAK.pdf

Download (27kB)
[img] Text (DAFTAR ISI)
TFK. 18-19 Mur p DAFTAR ISI.pdf

Download (35kB)
[img] Text (DAFTAR PUSTAKA)
TFK. 18-19 Mur p DAFTAR PUSTAKA.pdf

Download (77kB)
[img] Text (FULLTEXT)
TFK. 18-19 Mur p.pdf
Restricted to Registered users only until 12 September 2022.

Download (1MB) | Request a copy
Official URL: http://lib.unair.ac.id

Abstract

Objective: Breast cancer is malignancy in the breast tissue from the ductal or lobular epithelium. The increased risk of breast cancer is directly related to circulating estrogen levels. One of the management of breast cancer is hormonal therapy given as an adjuvant in stage I-IV breast cancer patients with positive hormonal immunohistochemical parameters (ER + / PR +). Non-steroidal aromatase inhibitor, letrozole, is a hormonal therapy that is often used but increase the risk of cardiovascular disease in postmenopausal women because its inhibition effect of estrogen formation in peripheral tissues. The aim of this study was to analyze the effects of letrozole on lipid profiles in postmenopausal breast cancer patients. Method: This research was prospective observational and approved by the ethics committee of the Surabaya Hajj Hospital. There were 17 sample who met the inclusion criteria. Taking and analyzing blood samples was carried out twice, in the 0th and 1st month in the Clinical Pathology laboratory of the Surabaya Hajj Hospital. Lipid profile were measured using the Cobas 501 Analyser. Result: There were 17 sample who met the inclusion criteria. 52.94% increased in TC levels, 35.29% increased in TG, 17.65% decreased in HDL and 64.71% increased in LDL. The results of the SPSS statistical analysis showed that there were no significant differences in all serum lipid parameters (TC, TG, HDL and LDL) in the 0th and 1st month. Conclusion: Letrozole therapy within 1 month have effect on increasing lipid profile in Total Cholesterol (TC) and Low Density Lipoprotein (LDL), but does not affect the triglyceride (TG) and High Density Lipoprotein (HDL).

Item Type: Thesis (Thesis)
Additional Information: KKB KK-2 TFK. 18-19 Mur p
Uncontrolled Keywords: Breast cancer, letrozole, total cholesterol, low density lipoprotein, triglyceride, high density lipoprotein.
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
R Medicine > RM Therapeutics. Pharmacology > RM300-666 Drugs and their actions
Divisions: 05. Fakultas Farmasi > Farmasi Klinis
Creators:
CreatorsEmail
LENDY NUGROHO WISNU MURTI, 051715153009UNSPECIFIED
Contributors:
ContributionNameEmail
ContributorDidik Hasmono, '0011095807UNSPECIFIED
ContributorEen Hendarsih, dr., Sp.PD-KHOMUNSPECIFIED
ContributorDewi Ramdani, Dra., M.Farm.Klin., AptUNSPECIFIED
Depositing User: Tatik Poedjijarti
Date Deposited: 12 Sep 2019 07:09
Last Modified: 12 Sep 2019 07:09
URI: http://repository.unair.ac.id/id/eprint/86610
Sosial Share:

Actions (login required)

View Item View Item