The potential of mangosteen (Garcinia mangostana) peel extract, combined with demineralized freeze‑dried bovine bone xenograft, to reduce ridge resorption and alveolar bone regeneration in preserving the tooth extraction socket

Utari Kresnoadi, NIDN. 0011015403 and Maretaningtias Dwi Ariani, NIDN. 0017038004 and Eha Djulaeha, NIDN. 0022075302 and NIKE HENDRIJANTINI, NIDN. 0006105908 (2017) The potential of mangosteen (Garcinia mangostana) peel extract, combined with demineralized freeze‑dried bovine bone xenograft, to reduce ridge resorption and alveolar bone regeneration in preserving the tooth extraction socket. The Journal of Indian Prosthodontic Society, 17 (3). pp. 282-288. ISSN 0972-4052

[img] Text (ARTIKEL)
NIKE 2.pdf

Download (1MB)
[img] Text (SIMILARITY)
3. A potential therapy of human umbilical cord mesenchymal stem cells for bone regeneration on osteoporotic mandibular bone.pdf

Download (2MB)
[img] Text (PEER REVIEW)
per nike 2.2.pdf

Download (776kB)
Official URL: http://www.j-ips.org/article.asp?issn=0972-4052;ye...

Abstract

Background: Following the extraction of a tooth, bone resorption can cause significant problems for a subsequent denture implant and restorative dentistry. Thus, the tooth extraction socket needs to be maintained to reduce the chance of any alveolar ridge bone resorption. Objective: The objective of this study is to determine whether the administration of mangosteen peel extracts MPEs), combined with demineralized freeze‑dried bovine bone xenograft (DFBBX) materials for tooth extraction socket preservation, could potentially reduce inflammation by decreased the expression of nuclear factor κβ (NfKb) and receptor activator of nuclear factor‑κβ ligand (RANKL), to inhibit alveolar bone resorption, and increased of bone morphogenetic protein‑2 (BMP2) expressions to accelerate alveolar bone regeneration. Materials and Methods: This study consists of several stages. First, a dosage of MPE combined with graft materials was applied to a preserved tooth extraction socket of a Cavia cobaya. Second, the C. cobaya was examined using immune histochemical expression of NfKb, RANKL, BMP2, as well as histology of osteoblasts and osteoclasts. The research was statistically analyzed, using an analysis of variance test and Tukey honest significant difference test. Results: The results of this research were that it was determined that MPEs combined with graft materials on a preserved tooth extraction socket can reduce NfKb, RANK, and osteoclasts also increase of BMP2 and osteoblast. Conclusion: The induction of MPEs and DFBBX is effective in reducing inflammation, lowering osteoclasts, decreasing alveolar bone resorption, and also increasing BMP2 expression and alveolar bone regeneration.

Item Type: Article
Uncontrolled Keywords: Bone morphogenetic protein‑2, graft materials, mangosteen peel extracts, nuclear factor κβ, preserved tooth extraction socket, receptor activator of nuclear factor‑κβ ligand expressions
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Prosthodontics
Creators:
CreatorsNIM/NIDN
Utari Kresnoadi, NIDN. 0011015403UNSPECIFIED
Maretaningtias Dwi Ariani, NIDN. 0017038004UNSPECIFIED
Eha Djulaeha, NIDN. 0022075302UNSPECIFIED
NIKE HENDRIJANTINI, NIDN. 0006105908UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 26 Sep 2019 04:06
Last Modified: 26 Sep 2019 04:06
URI: http://repository.unair.ac.id/id/eprint/87132
Sosial Share:

Actions (login required)

View Item View Item