The effect of low‑level estrogen in mandibular bone: An in vivo study

Nike Hendrijanti, NIDN. 0006105908 and Rostiny, NIDN. 0020095402 and Mefina Kuntjoro, NIDN. 0029097905 and Hanoem Eka Hidajati and Soekobagiono, NIDN. 0015125404 and Adi Subianto, NIDN0005055409 and Maretaningtias Dwi Ariani, NIDN. 0017038004 and Dika Agung Bakhtiar, 021218076305 (2019) The effect of low‑level estrogen in mandibular bone: An in vivo study. Dental Research Journal, 16 (2). pp. 63-70. ISSN 2008-0255

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Background: Low levels of estrogen can cause osteoporosis and usually occur during a woman’s menopausal phase. Osteoporosis can lead to bone resorption, the absence of osseointegration,and implant failure. The aim of this study is to determine the expression of transforming growth factor‑beta 1 (TGF‑β1), runt‑related transcription factor (RUNX2), and osteoblasts in mandibular rats with low levels of estrogen. Materials and Methods: This study is an in vivo experimental research. Female Wistar rats (n = 18)were divided into two groups: (1) Postsham surgery and (2) ovariectomy group. After 12 weeks,the rats were sacrificed to identify the level of estrogen, while histological analysis was conducted to determine the level of osteoblast and the expression of TGF‑β1 and RUNX2. The data were analyzed using t‑test (P < 0.05). Results: There were significant lower levels of estrogen and osteoblast among the ovariectomy group compared to the postsham group (P < 0.05). RUNX2 levels were found to be significantly higher in the ovariectomy group than that in the postsham group (P < 0.05). However, there were no significant differences between TGF‑β1 levels within the ovariectomy and postsham groups(P > 0.05). Conclusion: Ovariectomy can lead to decreased osteoblastogenesis in mandibular bone by the reduced level of osteoblast and the increased expression of TGF‑β1 and RUNX2.

Item Type: Article
Uncontrolled Keywords: Estrogens, osteoblasts, osteoporosis
Subjects: R Medicine
R Medicine > RK Dentistry
Divisions: 02. Fakultas Kedokteran Gigi > Prosthodontics
Nike Hendrijanti, NIDN. 0006105908UNSPECIFIED
Rostiny, NIDN. 0020095402UNSPECIFIED
Mefina Kuntjoro, NIDN. 0029097905UNSPECIFIED
Hanoem Eka HidajatiUNSPECIFIED
Soekobagiono, NIDN. 0015125404UNSPECIFIED
Adi Subianto, NIDN0005055409UNSPECIFIED
Maretaningtias Dwi Ariani, NIDN. 0017038004UNSPECIFIED
Dika Agung Bakhtiar, 021218076305UNSPECIFIED
Depositing User: Rudy Febiyanto
Date Deposited: 24 Sep 2019 01:27
Last Modified: 24 Sep 2019 01:27
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